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Rabbit Anti-LAMB1 Polyclonal Antibody#abs140697

Please note that the price provided is only for your reference. If you are interested in more specific pricing details, please contact our seller, Vecent. Thank you. Western blot analysis of extracts from HepG2 cells, using LAMB1 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs140697-50ug	1-2 Weeks	201.0
abs140697-100ug	1-2 Weeks	301.0

Please note that the price provided is only for your reference. If you are interested in more specific pricing details, please contact our seller, Vecent. Thank you.

Overview
catalog	abs140697
Other names	LAM B1, also known as Laminin B1 or Laminin beta 1 chain, is a protein associated with Cutis laxa with marfanoid phenotype. It plays a crucial role in maintaining the structural integrity of various tissues in the body. LAM B1 is encoded by the LAMB1 gene and is involved in the formation of laminin-1, laminin-2, laminin-6, laminin-8, laminin-10, and laminin-12 subunits. Cutis laxa with marfanoid phenotype is a rare genetic disorder characterized by abnormal connective tissue, resulting in loose and sagging skin. This condition often presents with features similar to Marfan syndrome, such as tall stature, joint hypermobility, and long limbs. LAM B1 is part of the laminin protein family, which plays a crucial role in cell adhesion, migration, and tissue organization. It forms a structural scaffold that supports the integrity of various tissues, including skin, blood vessels, and lungs. Mutations in the LAMB1 gene can lead to the production of abnormal laminin B1, resulting in the clinical manifestations of Cutis laxa with marfanoid phenotype. Understanding the role of LAM B1 and its association with Cutis laxa with marfanoid phenotype is essential for the diagnosis and management of individuals affected by this rare genetic disorder. Further research is needed to uncover the molecular mechanisms underlying this condition and develop targeted therapies for those affected.
Source	Rabbit
Specificity	The detection of total LAMB1 at endogenous levels is possible with the LAMB1 Antibody. To provide an alternative presentation, the following content is based on the same information as the original text but rearranged for a highly similar yet different output: Endogenous levels of total LAMB1 can be effectively identified using the LAMB1 Antibody. This antibody enables precise detection and measurement of LAMB1 levels within the biological system, allowing researchers to gain valuable insights into its role and function. By offering a reliable means of analyzing total LAMB1, the LAMB1 Antibody opens up opportunities for further investigations into various cellular processes.
Species Reactivity	Human;Mouse
Antigen	LAMB1
Application	，： 1:500~1:1000, （IHC）：1:50~1:200, （IF/ICC）：1:100-1:500, （ELISA）()：1:20000-1:40000。，，。
Immunogen	A synthesized peptide.
MW	220 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid repeated cycles of freezing and thawing as this can have a negative impact on the integrity of the product. Taking these precautions will help to ensure that the product remains stable and effective for use over an extended period of time.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4. The solution also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20°C and it remains stable for up to 12 months from the date of receipt. Please use caution and follow appropriate safety protocols when handling.
Target
Background	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P07942