Rabbit Anti-Interleukin5 Polyclonal Antibody#abs131200

abs131200-50ug

1-2 Weeks

201

abs131200-100ug

1-2 Weeks

301

Description

A factor that causes the final stage of maturation in B-cells, resulting in secretion of immunoglobulins, is sought after. To rephrase this, we need to use synonyms and alternative phrases while conveying the same idea. Hence, a possible alternative could be: we need to identify the factor that triggers terminal differentiation in the late-developing B-cells, leading to the production of immunoglobulins.

Other names

B-cell differentiation factor I, also known as interleukin 5 (IL-5), is a colony stimulating factor that plays a critical role in the differentiation and activation of eosinophils. IL-5 is also called eosinophil differentiation factor (EDF) due to its ability to stimulate the growth and differentiation of eosinophilic progenitor cells. This cytokine is essential for the survival and function of eosinophils and has been implicated in several inflammatory disorders, including asthma, allergic rhinitis, and eosinophilic esophagitis.
IL-5 was originally identified as a T cell replacing factor (TRF) that could stimulate the production of immunoglobulin by B cells. However, subsequent research revealed that IL-5 primarily targets eosinophils and other cells of the myeloid lineage. IL-5 is produced by activated T cells and mast cells and acts through its receptor, IL-5R, which is expressed on the surface of eosinophils and some other myeloid cells.
IL-5 has several functions in eosinophil biology, including promoting their survival, proliferation, and activation. IL-5 also stimulates the production of cytokines and chemokines that attract and activate other immune cells, promoting the development of inflammatory responses. In addition to its roles in eosinophil biology, IL-5 has been shown to have effects on other cell types, including B cells and dendritic cells.
Overall, IL-5 is a critical regulator of eosinophil development and function and plays an important role in the pathogenesis of several inflammatory disorders. Understanding the mechanisms of IL-5 signaling and regulation may lead to the development of new therapies for these diseases.

Source

Rabbit

Specificity

The Interleukin 5 Antibody has been designed to identify total Interleukin 5 at its natural levels within the body. This means that it is capable of detecting Interleukin 5 in its endogenous state.

Application

，。WB1:500-1:2000，IHC1:50-1:200，ELISA1:20000-1:40000。

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Properties

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be generated by rearranging these words and maintaining the original context of the sentence.

Clonality

Polyclonal Antibody

To ensure optimal preservation, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this may compromise its quality.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation ensures the stability of the IgG for a period of 12 months from the date of receipt. It is important to adhere to these storage guidelines to maintain the integrity and effectiveness of the product.

Target

Background

Terminal differentiation of late-developing B-cells to immunoglobulin secreting cells is influenced by a factor. Let's explore the factor that triggers this process. To generate highly similar content, we'll rearrange the original text information.

Celluar localization

P05113