Rabbit Anti-NDF2 Polyclonal Antibody #abs130477

abs130477-50ug

1-2 Weeks

201

abs130477-100ug

1-2 Weeks

301

Description

A possible rearrangement and rephrasing of the original content could be:
The role of NEUROD2 in promoting neuronal differentiation is thought to be achieved through its involvement in mediating the process. For efficient DNA binding, NEUROD2 needs to form a dimer with another bHLH protein. This dimerization is crucial for NEUROD2 to effectively bind to DNA and regulate the expression of target genes associated with neuronal differentiation.

Other names

NeuroD-related factor, also known as neurogenic differentiation 2 or NDF2_HUMAN, is a class A basic helix-loop-helix protein 1. Its aliases include NDR2 and NDRF. This protein plays a crucial role in neurogenesis by promoting differentiation of neuronal cells. Its expression is primarily observed in the brain, spinal cord, and pancreas. Dysfunction of this protein has been linked to several neurological disorders. Overall, the bHLHa1 protein remains a promising target for therapeutic interventions in neurodegenerative diseases.

Source

Rabbit

Specificity

NDF2 Antibody detects endogenous levels of NDF2

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human NDF2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

-20°C，。/。

Storage buffer

This product is Rabbit IgG in phosphate buffered saline (PBS) with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage, it should be kept at -20 °C. It has a shelf life of 12 months from the date of receipt.

Target

Background

This transcriptional regulator is heavily implicated in the determination of neurons. It is responsible for activating calcium-dependent transcription by binding to promoters that contain E boxes. In addition, it has been identified as a critical factor in preventing the formation of synaptic vesicle clusters at the presynaptic membrane in mature neurons, effectively inhibiting the genetic program for neuronal differentiation.
Interestingly, this transcriptional regulator induces the expression of ZEB1, which functions as a negative regulator of neuronal differentiation by reducing the expression of REST. It has also been implicated in the development of thalamocortical connections, specifically in the segregation of thalamic afferents into distinct barrel domains in the somatosensory cortex. Further, it plays a role in the development of granular neurons in the cerebellum and hippocampus, and in neurons of the basolateral nucleus of the amygdala and the hypothalamic-pituitary axis.
By interacting with chromatin, this transcriptional regulator is able to promote the expression of genes that contain E box-containing promoters, such as DPYSL3. Overall, this protein is a central player in neuronal differentiation and development, acting as a key transcriptional regulator to ensure proper neuronal formation and function.

Celluar localization

Nucleus;

UniPort

Q15784