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Rabbit Anti-MYST3 Polyclonal Antibody#abs138544

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Description

Catalog-specification	Delivery time	USD price
abs138544-100ug	1-2 Weeks	301.0
abs138544-50ug	1-2 Weeks	201.0

Overview
catalog	abs138544
Other names	MYST3, also known as Histone acetyltransferase MYST3, is a protein that plays a crucial role in various biological processes. It is also referred to as Monocytic leukemia zinc finger protein, MOZ, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, MYST histone acetyltransferase (monocytic leukemia) 3, and MYST protein 3. Other aliases include MYST-3, MYST3_HUMAN, OTTHUMP00000197392, OTTHUMP00000197394, and OTTHUMP00000225722. One of the functions of MYST3 is its involvement in transcription regulation, particularly in the binding of the Runt-related transcription factor 2 (RUNXBP2). This interaction is critical for the proper functioning of RUNXBP2 in gene expression regulation. Additionally, MYST3 acts as a histone acetyltransferase, modifying histone proteins by adding acetyl groups. This modification is vital for chromatin remodeling and transcriptional activation. Moreover, MYST3 plays a role in DNA repair processes and is implicated in monocytic leukemia. Overall, MYST3, also known as ZC2HC6A or Zinc finger protein 220, is a multifunctional protein involved in diverse cellular functions and biological processes.
Source	Rabbit
Specificity	Endogenous levels of total MYST3 can be detected using the MYST3 Antibody. The antibody is specifically designed to bind and identify MYST3 proteins present within the body. By accurately detecting the endogenous levels of MYST3, the antibody aids in studying the expression and function of this protein in various biological processes and diseases. Whether it is examining MYST3's role in gene regulation, cellular signaling, or its potential as a therapeutic target, the MYST3 Antibody provides researchers with a valuable tool for investigating this protein's biology and potential implications.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	MYST3
Application	The recommended dilutions for WB are 1:1000-3000, 1:200 for IHC, and 1:20000-1:40000 for ELISA (peptide). Please note that the dilution ratios may vary based on the specific experiment or protocol used. It is important to carefully optimize the dilutions to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide derived from human MYST3.
MW	225 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum with peptide affinity chromatography. The process ensured that the final product was highly purified and specific to the desired target antigen.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Posttranslational modification	Autoacetylation at Lys-604 is required for proper function (By similarity). Autoacetylated.Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.
Celluar localization	Cytosol;Nucleus;
UniPort	Q92794