Rabbit Anti-PRKCI Polyclonal Antibody#abs133055

abs133055-100ug

1-2 Weeks

301.0

abs133055-50ug

1-2 Weeks

201.0

catalog

Description

This enzyme is a phospholipid-dependent, calcium-independent kinase that specifically targets serine and threonine residues. It is believed to play a significant role in the cellular response to nutrients, particularly in the secretory processes. Additionally, it is involved in the regulation of cell polarization and the formation of tight junctions in epithelial cells. This kinase has been implicated in the activation of various signaling pathways, including Ras, c-Src, and NF-kappa-B pathways. Its function extends to both pro- and anti-apoptotic pathways. Furthermore, it participates in the RAC1/ERK signaling pathway crucial for transformed growth. Another important aspect of its role is its influence on microtubule dynamics, which it achieves by interacting with RAB2A and GAPDH and recruiting them to vesicular tubular clusters (VTCs).

Concentration

1mg/ml

Target

Background

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.