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Rabbit Anti-NFAM1 Polyclonal Antibody#abs138546

Description

Catalog-specification	Delivery time	USD price
abs138546-100ug	1-2 Weeks	301.0
abs138546-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138546
Other names	，。 NFAT activation molecule 1 precursor is a protein that activates calcineurin and NFAT through its ITAM-containing domain. It is also known as CNAIP. This protein plays a crucial role in regulating immune responses and cellular functions. Through rearranging the provided information, a highly similar content can be generated as follows: CNAIP, also referred to as NFAT activation molecule 1 precursor, is a protein that contains an ITAM domain. It facilitates the activation of calcineurin and NFAT, thereby influencing immune responses and cellular functions.
Source	Rabbit
Specificity	The detection of total NFAM1 is possible using the NFAM1 Antibody, which is designed to target endogenous levels of the protein. By detecting NFAM1, researchers can analyze its presence and functionality within cells and tissues. This antibody provides a valuable tool for studying NFAM1 and understanding its role in various biological processes.
Species Reactivity	Human
Antigen	NFAM1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NFAM1.
MW	30kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. The resulting product was highly pure and effective, making it an ideal candidate for use in various applications. Overall, we are confident in the quality and reliability of this antiserum for use in research and diagnostic settings.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, the product should be stored for one year at a temperature of -20 °C. It is important to avoid subjecting it to repeated freeze/thaw cycles during this time.
Storage buffer	This solution contains Rabbit IgG in a phosphate buffered saline with a pH of 7.4, along with 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20°C, as it is stable for up to 12 months from the date of receipt.
Target
Background	This protein may play a vital role in our immune system, acting as a receptor that activates cytokine gene promoters via the calcineurin/NFAT-signaling pathway. By activating the transcription of promoters for cytokines such as IL-13 and TNF-alpha, it can facilitate the immune response. Moreover, this protein may also regulate B-cell development, but not T-cell development. Interestingly, its overexpression can activate downstream effectors even without ligand binding or antibody cross-linking. All in all, this protein's functions are still being studied, but the current knowledge suggests that it is essential for immune regulation and may have a broader role in cellular signaling.
Tissue specificity	Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
Posttranslational modification	N-glycosylated.
Celluar localization	Lysosome;Plasma Membrane;
UniPort	Q8NET5