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Rabbit Anti-PDCD6IP Polyclonal Antibody#abs138547

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Description

Catalog-specification	Delivery time	USD price
abs138547-100ug	1-2 Weeks	301.0
abs138547-50ug	1-2 Weeks	201.0

Overview
catalog	abs138547
Other names	AIP1, also known as ALG 2 interacting protein 1 or Alix, is a protein that interacts with ALG-2 and plays a role in apoptosis. It is also known as dopamine receptor interacting protein 4 (DRIP4), programmed cell death 6 interacting protein, or PDCD6IP. AIP1 is encoded by the KIAA1375 gene and is sometimes referred to as ALG2 interacting protein X or Hp95. Other aliases for this protein include MGC17003 and PDCD6-interacting protein. AIP1 is important for mediating various cellular processes, including endosomal sorting, cytokinesis, and viral budding.
Source	Rabbit
Specificity	The detected levels of total PDCD6IP in the body are recognized by the PDCD6IP Antibody. To create similar content based on the original text, the information can be rearranged to state that the antibody is capable of identifying endogenous quantities of PDCD6IP.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine
Antigen	PDCD6IP
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PDCD6IP.
MW	96 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, keep the store temperature at -20 °C for a period of one year. It is important to avoid subjecting the item to repeated freeze/thaw cycles during this time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).
Posttranslational modification	May be phosphorylated on tyrosine residues by activated PDGFRB.
Celluar localization	Cytoskeleton;Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	Q8WUM4