Rabbit Anti-FOXP1 Polyclonal Antibody#abs131146

abs131146-50ug

1-2 Weeks

201

abs131146-100ug

1-2 Weeks

301

Description

As a transcriptional repressor, this protein is crucial for the development and identity of lung epithelial cells. It has been observed to work alongside CTBP1 to effectively silence transcription, although CTBP1 is not always required. Furthermore, it serves as an indispensable regulator of B cell differentiation, controlling gene expression throughout this complex process. Overall, this protein's ability to suppress transcription represents an essential aspect of numerous biological processes, particularly in the context of tissue development and cellular differentiation.

Other names

FOXP1, also known as Fork head related protein like B or Forkhead box protein P1, is a glutamine rich factor 1 that plays a crucial role in regulating gene expression. This protein is implicated in various developmental processes and is involved in the control of cell proliferation, migration and survival. FOXP1 is also associated with numerous human diseases, including cancer. Moreover, FOXP1 is expressed in a variety of tissues, suggesting a diverse functional role for this transcription factor. As such, the study of FOXP1 may provide valuable insights into both developmental biology and disease pathogenesis.

Source

Rabbit

Specificity

Endogenous total FOXP1 protein can be accurately measured by the antibody. Let me generate a highly similar content by rearranging the above information.

Application

，：
，ELISA（）1:200001:40000，WB1:5001:1000。

Peptide sequence around aa. 669~673 (D-E-P-V-N.

Properties

1mg/ml

Purification

Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.

Clonality

Polyclonal Antibody

To ensure the stability and longevity of the product, it is essential to store it at a temperature of -20 °C for a period of one year. Avoiding any further freeze/thaw cycles is crucial to maintain the product's quality and efficacy. It is important to note that any exposure to fluctuating temperatures could compromise the product's integrity over time. Therefore, it is strongly recommended to strictly comply with the storage guidelines to achieve optimal results.

Storage buffer

This solution contains a concentration of 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+). It has a pH level of 7.4 and consists of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Please note that the generated content is based on the original text information but presented in a different manner.

Target

Background

This protein is known to act as a transcriptional repressor, according to research published on PubMed. Its role in synergistically repressing transcription can be assisted by CTBP1, but this molecule is not essential. The protein plays an important role in the development and differentiation of lung epithelium, cooperating with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program. In addition to this, the protein is an essential transcriptional regulator of B-cell development and plays a vital role in regulating cardiac muscle cell proliferation. Its function is also important in the columnar organization of spinal motor neurons, where it promotes the formation of the lateral motor neuron column and the preganglionic motor column. Cooperation with other Hox proteins is required for the segment-appropriate generation of spinal chord motor columns.
The protein can also regulate PITX3 promoter activity, possibly promoting midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Additionally, it negatively regulates the differentiation of T follicular helper cells. The protein is involved in maintenance of hair follicle stem cell quiescence and negatively regulates androgen receptor signaling.
Research suggests that the protein can repress transcription of various pro-apoptotic genes and cooperate with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. It also activates the CSF1R promoter elements, and is involved in the regulation of monocyte differentiation and macrophage functions. Repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Lastly, the protein is involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis. Its role in neovascularization seems to implicate suppression of SEMA5B.

Tissue specificity

Isoform 8 is specifically expressed in embryonic stem cells.

Celluar localization

Q9H334