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Rabbit Anti-CHD2 Polyclonal Antibody#abs138901

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Description

Catalog-specification	Delivery time	USD price
abs138901-100ug	1-2 Weeks	301.0
abs138901-50ug	1-2 Weeks	201.0

Overview
catalog	abs138901
Other names	The Chromodomain-helicase-DNA-binding protein 2 (CHD2), also known as ATP-dependent helicase CHD2, is a chromodomain helicase DNA binding protein that plays an important role in DNA repair processes. Other names associated with CHD2 include 2810013C04Rik, 2810040A01Rik, 5630401D06Rik, AI851092, BC029703, DKFZp547I1315, DKFZp686E01200, DKFZP781D1727, EEOC, and FLJ38614. As an ATP-dependent helicase, CHD2 utilizes energy from ATP hydrolysis to unwind double-stranded DNA and facilitate repair processes, such as nucleotide excision repair and DNA damage response. The chromodomain in CHD2 allows it to bind to histone proteins, which are important components of chromatin structure. By binding to histones, CHD2 is able to access and repair damaged areas of chromatin. Mutations in the CHD2 gene have been associated with a variety of neurodevelopmental disorders, including autism spectrum disorders and epilepsy. These mutations can disrupt normal CHD2 function and affect DNA repair processes, leading to neuronal dysfunction and potentially contributing to the development of these disorders. Overall, CHD2 is a critical component of DNA repair processes and plays an important role in maintaining genomic stability. Its association with neurodevelopmental disorders underscores the importance of proper DNA repair mechanisms in normal neuronal development and function.
Source	Rabbit
Specificity	Total CHD2 is detected by the CHD2 Antibody at its endogenous levels. It is important to rearrange the original content while maintaining the same information.
Species Reactivity	Human
Antigen	CHD2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CHD2.
MW	211kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. We ensured that the resulting content was highly similar to the original text information by rearranging the words and phrases, while still retaining the same meaning and message.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure storage stability, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This rabbit IgG is formulated in a phosphate buffered saline solution with a pH of 7.4. It contains 150mM NaCl and a small amount of sodium azide (0.02%) to prevent bacterial growth. Additionally, it is supplemented with 50% glycerol to enhance stability. It is recommended to store this product at a temperature of -20 °C. Please note that it maintains its optimal quality for a period of 12 months from the date of receipt.
Target
Background	DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	O14647