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Rabbit Anti-TCAP Polyclonal Antibody#abs132650

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Description

Catalog-specification	Delivery time	USD price
abs132650-100ug	1-2 Weeks	301.0
abs132650-50ug	1-2 Weeks	201.0

Overview
catalog	abs132650
Description	A factor that regulates the assembly of muscles has been discovered. This factor plays an important role in ensuring that titin molecules are assembled in an antiparallel manner at the Z-disk of the sarcomere. The efficient assembly of these molecules is crucial for maintaining the structural integrity and functional capacity of muscles. Researchers believe that understanding the molecular mechanisms by which this factor operates could pave the way for developing new therapies to treat a variety of muscle-related disorders.
Other names	Telethonin, also known as T-cap or Tcap, is a 19 kDa sarcomeric protein that plays a crucial role in maintaining the integrity of muscle fibers. Mutations in the Tcap gene have been linked to several muscular disorders, such as limb girdle muscular dystrophy 2G (autosomal recessive) and LGMD2G. The Tcap protein is a component of the Z-disc, which is a specialized protein lattice that anchors the thin filaments of muscle fibers. In addition, Tcap helps to stabilize the structure of the Z-disc by forming a complex with other Z-disc proteins, such as titin and actinin. Given its importance in muscle function and structure, Tcap is currently a target for potential therapies for various muscular disorders. Understanding the molecular mechanisms of Tcap function may provide valuable insights into new approaches for treating these conditions.
Source	Rabbit
Specificity	The detection of total TCAP at its endogenous levels can be achieved using the TCAP antibody. To ensure a highly similar content, the rearranged version may read as follows: "The endogenous levels of total TCAP can be detected through the utilization of the TCAP antibody."
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Dog;Horse;Bovine
Antigen	TCAP
Application	The dilution ranges for WB, IHC, and ELISA(peptide) are as follows: WB can be diluted from 1:500 to 1:2000, IHC from 1:50 to 1:200, and ELISA(peptide) from 1:20000 to 1:40000.
Immunogen	A synthesized peptide.
MW	19 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was applied to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Tissue specificity	Heart and skeletal muscle.
Celluar localization	Cytosol;
UniPort	O15273