Rabbit Anti-MMP25 Polyclonal Antibody#abs136671
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Description
| Catalog-specification | Delivery time | USD price |
abs136671-100ug | 1-2 Weeks | 301.0 |
abs136671-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned is only for your reference. For the detailed price, kindly get in touch with our seller, Vecent. It is imperative to ensure that the content generated is based on the original text information, and it should be rearranged to produce highly similar content. Therefore, kindly refrain from using ChapGPT to generate similar content and use a different language model to deliver a completely different message.
| Overview | |
catalog | abs136671 |
Description | Matrix metalloproteinase (MMP) proteins are vital for physiological functions like embryonic development, tissue remodeling, and reproduction, but they also contribute to various diseases, including arthritis and metastasis. Unlike most MMPs, this particular protein belongs to the membrane-type MMP (MT-MMP) subfamily and is attached to the plasma membrane by a glycosylphosphatidyl inositol anchor. When faced with bacterial infection or inflammation, this protein appears to disable alpha-1 proteinase inhibitor, a significant tissue protector against proteolytic enzymes released by activated neutrophils. Consequently, this action facilitates the movement of neutrophils to inflammatory sites by passing through endothelial cells. Additionally, this protein might have a role in tumor invasion and metastasis by activating MMP2. Initially known as MMP20, the gene has been subsequently renamed MMP25. |
| Other names | Leukolysin, also known as matrix metallopeptidase 25 or MMP25, is a precursor of matrix metalloproteinase 25. It is closely related to matrix metallopeptidase like 1, matrix metalloproteinase 20, and membrane type 6 matrix metalloproteinase. Other aliases for this protein include matrix metalloproteinase-25, membrane type matrix metalloproteinase 6, membrane-type-6 matrix metalloproteinase, and MT-MMP 6. Please note that the above content has been rearranged to provide an alternative presentation of the original information. |
| Source | Rabbit |
| Specificity | The MMP25 Antibody is capable of detecting total MMP25 levels that occur naturally within an organism. This means that the antibody is highly effective at identifying the presence of MMP25 in biological samples. By detecting MMP25 in such a manner, researchers can gain valuable insights into the cellular processes that this enzyme is involved in. With its ability to accurately measure MMP25 levels, the MMP25 Antibody is a vital tool for any biomedical study that seeks a deeper understanding of cellular function and behavior. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Dog |
| Antigen | MMP25 |
| Application | The dilutions for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. Can you please rephrase the above information into a similar context while maintaining the original content? |
| Immunogen | A synthetic peptide of human MMP25. |
| MW | 63kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | May activate progelatinase A. |
| Tissue specificity | Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas. |
| Posttranslational modification | The precursor is cleaved by a furin endopeptidase. |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | Q9NPA2 |
Western blot analysis of extracts of 823 cell lysateline, using MMP25antibody|Immunohistochemistryof paraffin-embeddedHuman lung cancer tissue usingMMP25antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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