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Rabbit Anti-TRIP4 Polyclonal Antibody#abs133597

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Description

Catalog-specification	Delivery time	USD price
abs133597-100ug	1-2 Weeks	301.0
abs133597-50ug	1-2 Weeks	201.0

Overview
catalog	abs133597
Other names	To activate the signal cointegrator 1, one can also use ASC 1 or ASC-1, which is also known as HsT17391. Another option is to use Thyroid hormone receptor interactor 4, also called Thyroid receptor interacting protein 4 or TR-interacting protein 4, and abbreviated as TRIP 4 or TRIP-4. This protein is also known as Trip4 and is encoded by the ZC2HC5 gene, which belongs to the zinc finger C2HC5 type family.
Source	Rabbit
Specificity	The TRIP4 Antibody is capable of identifying the total TRIP4 protein levels in our bodies.
Species Reactivity	Human;Mouse
Antigen	TRIP4
Application	The dilution range for Western blot (WB) is 1:500 to 1:1000, while for immunofluorescence (IF) and immunocytochemistry (ICC), it is 1:100 to 1:500. For ELISA using peptide antigens, the recommended dilution range is 1:20000 to 1:40000. It is important to adhere to these dilution guidelines to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	66 KD
Properties
Concentration	1mg/ml
purification	Our team successfully purified the antiserum through peptide affinity chromatography, utilizing the effective SulfoLink™ Coupling Resin. This process ensured that the final product was of high purity and quality, ready for further use in research and development.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, keep the store at -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline, with a pH level of 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% glycerol. The recommended storage temperature is -20 °C, and it is advised to store it for at least 12 months from the time of receipt to ensure its stability. To summarize, this substance is best kept in the aforementioned conditions to maintain its integrity and activity.
Target
Background	Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity).
Posttranslational modification	Phosphorylated by NEK6.Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q15650