Phospho-PAK1/2/3 (S144+S141+S139) Rabbit Polyclonal Antibody#abs133283
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Description
| Catalog-specification | Delivery time | USD price |
abs133283-100ug | 1-2 Weeks | 301.0 |
abs133283-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For detailed pricing information, please get in touch with our sales representative, Vecent. It is important to note that the content generated should be based on the original text information but rearranged in a highly similar manner, without relying on the ChapGPT method of content generation. Let's communicate in a manner that involves generating text using language models that differ significantly from ChapGPT-generated conversation.
| Overview | |
catalog | abs133283 |
| Other names | PAK1 (p21-activated kinase 1), also known as Alpha PAK, is a serine/threonine protein kinase that plays a crucial role in various cellular processes. It is also referred to as Alpha-PAK, p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related), or p21-activated kinase 1. PAK1 is involved in the regulation of cell adhesion, migration, proliferation, and cell cycle progression. Another member of the PAK family is PAK2 (p21-activated kinase 2), also known as Gamma PAK or PAK-2. Along with PAK1, PAK2 is a serine/threonine protein kinase that mediates intracellular signaling pathways. PAK2 is implicated in the regulation of cytoskeletal dynamics and cell motility. PAK3 (p21-activated kinase 3) is another isoform of the PAK family. It is also known as hPAK3 or MRX30/MRX47. PAK3 is primarily expressed in the brain and plays a crucial role in neuronal development. Mutations in PAK3 are associated with X-linked intellectual disability. Overall, the PAK family of kinases, including PAK1, PAK2, and PAK3, are involved in cellular processes such as cytoskeletal reorganization, cell migration, and synaptic plasticity. They are essential mediators of intracellular signaling pathways and have been implicated in various diseases, including cancer and neurological disorders. The diverse range of PAK isoforms underscores their significance in cellular homeostasis and highlights their potential as therapeutic targets. |
| Source | Rabbit |
| Specificity | The Antibody for phospho-PAK1/2/3 (S144+S141+S139) recognizes the phosphorylated form of PAK1/2/3 at PS144+S141+S139 and is capable of detecting endogenous levels of these proteins. In order to provide a highly similar content by rearranging the above information, please see the revised statement below: Endogenous levels of PAK1/2/3 can be accurately detected using the Phospho-PAK1/2/3 (S144+S141+S139) Antibody, which specifically targets the phosphorylated state of these proteins at PS144+S141+S139. By detecting the phosphorylated forms, this antibody enables researchers to study the activity and function of PAK1/2/3 under physiological conditions. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | PAK1/2/3 |
| Application | WB 1:1000-3000, IHC 1:200, ICC/IF, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide derived from human Phospho-PAK1/2/3 (S144+S141+S139). |
| MW | 65kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. |
| Tissue specificity | Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. |
| Posttranslational modification | Autophosphorylated when activated by CDC42/p21.Neddylated. |
| Celluar localization | Cytosol;Endosome;Plasma Membrane; |
| UniPort | O75914/Q13153/Q13177 |
Western blot analysis Phospho-PAK1/2/3 (S144+S141+S139) using HT-29 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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