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Rabbit Anti-AGR2 Polyclonal Antibody#abs137332

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Description

Catalog-specification	Delivery time	USD price
abs137332-100ug	1-2 Weeks	301.0
abs137332-50ug	1-2 Weeks	201.0

Overview
catalog	abs137332
Other names	AG 2 is a protein of the protein disulphide isomerase family. It is also known as Anterior Gradient 2 Homolog and has homology to the Xenopus laevis protein. Other names for this protein include AGR 2, GOB 4, HAG 2, HEL S 116, and PDIA17. AG 2 is involved in various biological processes, including cancer development and epididymis secretion. This secreted cement gland protein XAG 2 homolog is a potential target for cancer therapy and further research may reveal its use in treating various disease states. Considerable interest surrounds the potential of AG 2 and research continues to be undertaken to explore its therapeutic value.
Source	Rabbit
Specificity	The total AGR2 levels can be detected by the AGR2 Antibody, which is capable of recognizing endogenous levels of AGR2.
Species Reactivity	Human;Mouse
Predictive reaction species	Bovine
Antigen	AGR2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human AGR2.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).
Tissue specificity	Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Mitochondrion;
UniPort	O95994