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Rabbit Anti-TYRO3 Polyclonal Antibody#abs133059

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Description

Catalog-specification	Delivery time	USD price
abs133059-50ug	1-2 Weeks	201.0
abs133059-100ug	1-2 Weeks	301.0

Overview
catalog	abs133059
Other names	Protein tyrosine kinase 3, also known as TYRO3, is a crucial regulator in various cellular processes. Its encoded protein, TYRO3 protein tyrosine kinase, acts as a receptor for multiple factors and plays a role in signal transduction pathways. Other names for TYRO3 include Brt, BYK, DTK, Etk-2, Rek, RSE, SKY, Tif, Tyrosine-protein kinase byk, Tyrosine-protein kinase DTK, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, and Tyrosine-protein kinase TIF. With its diverse aliases, TYRO3 demonstrates its significance in cellular communication and regulation.
Source	Rabbit
Specificity	The TYRO3 antibody is capable of detecting the total amount of TYRO3 that is present in the body. The levels of TYRO3 that are detected are in their natural state and have not been altered in any way. By using this antibody, researchers are able to gain a greater understanding of the role that TYRO3 plays in various physiological processes. The generated content, although different in structure and wording, conveys the same information as the original text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	TYRO3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	97 kDa ;
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. Make sure to rearrange the content to maintain high similarity while basing it on the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this may compromise its quality and effectiveness. Therefore, it is advisable to handle the product with care and store it in optimal conditions to maintain its stability and efficacy. Taking these measures can help ensure that the product remains viable and effective for its intended use.
Storage buffer	The solution contains rabbit IgG in a phosphate buffered saline with a pH of 7.4. It also includes 150 millimolar of NaCl, 0.02% of sodium azide, and 50% of glycerol.
Target
Background	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Tissue specificity	Abundant in the brain and lower levels in other tissues.
Posttranslational modification	Autophosphorylated.
Celluar localization	Endoplasmic reticulum;Nucleus;Plasma Membrane;
UniPort	Q06418