Rabbit Anti-Na+ CP Type VIIalpha Polyclonal Antibody#abs140475
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Description
| Catalog-specification | Delivery time | USD price |
abs140475-100ug | 1-2 Weeks | 301.0 |
abs140475-50ug | 1-2 Weeks | 201.0 |
Please note that the mentioned price is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. In order to generate a highly similar content, the original text information will be rearranged. However, it is important to avoid using the dialogue-based method of generating content and instead focus on producing text in a completely different manner using the language model.
| Overview | |
catalog | abs140475 |
| Other names | The putative voltage gated sodium channel subunit alpha, also known as Nax, is a critical component of the sodium channel that regulates the movement of sodium ions across cell membranes. It is encoded by the SCN 6A, SCN 7A, and SCN6A genes, and plays an essential role in the proper functioning of both cardiac and skeletal muscles. This alpha subunit belongs to the sodium channel protein family, specifically type 7 and VII subunit alpha. It is responsible for creating an electrical gradient between the inside and outside of cells, which allows for the generation and transmission of nerve impulses and muscle contractions. Problems with the alpha subunit can cause a range of conditions, including epilepsy, muscle weakness, paralysis, and heart arrhythmias. When functioning properly, the alpha subunit confers a voltage dependent nature to the sodium channel, enabling it to open and close in response to changes in the membrane potential. This property is critical for maintaining proper cell excitability and has implications for a range of physiological processes. Understanding the structure and function of the voltage gated sodium channel alpha subunit is crucial for the development of new drugs and therapies to treat these debilitating conditions. |
| Source | Rabbit |
| Specificity | The Na+ CP type VIIalpha Antibody is capable of detecting the total amount of endogenous Na+ CP type VIIalpha. Take note that the following content is a rearrangement of the original text information, while ensuring similarity and accuracy. |
| Species Reactivity | Human |
| Antigen | Na+ CP type VIIalpha |
| Application | WB 1:1000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | Na+ CPVIIalpha。，。 |
| MW | 200kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. We employed a method that involved isolating specific peptides through their affinity to the resin to obtain a highly purified antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain its quality, it is advised to keep the product in a freezer set at a temperature of -20°C for up to a year. It is recommended to avoid exposing the product to multiple freeze/thaw processes. |
| Storage buffer | This product is Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. To maintain the integrity of the product, it is recommended to store it at a temperature of -20 °C. This solution is stable for up to 12 months from the date of receipt. |
Target | |
Background | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. |
| Tissue specificity | Heart and uterus. |
| Posttranslational modification | Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 656) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Celluar localization | Plasma Membrane; |
| UniPort | Q01118 |
Western blot analysis Na+ CP type VIIalpha using RAW264.7 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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