Rabbit Anti-Na+ CP Type IXalpha Polyclonal Antibody#abs140474
Please note that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis Na+ CP type IXalpha using RAW whole cell lysates This product is for research use only, not for...
Description
| Catalog-specification | Delivery time | USD price |
abs140474-100ug | 1-2 Weeks | 301.0 |
abs140474-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.
| Overview | |
catalog | abs140474 |
| Other names | The Neuroendocrine sodium channel, also known as ETHA, GEFSP7, or hNE Na, plays a crucial role in regulating sodium ion flow in the nervous system. It is encoded by the SCN9A gene and is a subtype of the voltage-gated sodium channel family, specifically Nav1.7. This channel is primarily found in peripheral nerves and is involved in transmitting pain signals. The Sodium channel protein type 9 subunit alpha, or hNE-Na, is responsible for the functioning of this sodium channel. It acts as a gatekeeper, allowing sodium ions to flow across the neuronal membrane, thus generating electrical signals that contribute to nerve impulse conduction. PN1 or Peripheral sodium channel 1, is another name for this channel, which highlights its presence in the peripheral nervous system. The Sodium channel voltage gated type IX alpha polypeptide is the specific subunit alpha of the voltage-gated sodium channel Nav1.7. This protein is encoded by the SCN9A gene and is primarily expressed in sensory neurons. Understanding the intricacies of the Neuroendocrine sodium channel and its various names, such as hNENa, NE NA, NENA, and voltage-gated sodium channel subunit alpha Nav1, is essential for studying the mechanisms of pain perception and developing novel pain relief medications. Further research on this channel may lead to advancements in treating chronic pain and related disorders. |
| Source | Rabbit |
| Specificity | The Na+ CP type IXalpha Antibody is capable of detecting total levels of endogenous Na+ CP type IXalpha. |
| Species Reactivity | Human;Mouse |
| Predictive reaction species | Pig;Chicken;Sheep;Dog;Horse;Bovine; |
| Antigen | Na+ CP type IXalpha |
| Application | WB 1:1000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | Na + CPIXalpha，，。，ChapGPT，。 |
| MW | 220kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography purification of the antiserum. The antiserum was purified to a high degree using this method. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na+ channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). |
| Tissue specificity | Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. |
| Posttranslational modification | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. |
| Celluar localization | Plasma Membrane; |
| UniPort | Q15858 |
Western blot analysis Na+ CP type IXalpha using RAW whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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