VLDLR Antibody (Center) #abs110390

abs110390-50ul

In Stock

228

Description

Rabbit polyclonal antibody (Pab) purified by peptide affinity is available. To produce content similar to the original text, we could rephrase it as follows: We have a peptide affinity purified rabbit polyclonal antibody (Pab) in our inventory.

Other names

The VLDL receptor, also known as very low-density lipoprotein receptor or VLDLR, plays a crucial role in regulating lipid metabolism. Its primary function is to bind and internalize VLDL particles which are rich in triglycerides and cholesterol. This receptor is expressed in many tissues including the liver, adipose tissue, and muscle. Dysregulation of the VLDLR pathway can lead to a range of metabolic disorders including hyperlipidemia, atherosclerosis, and fatty liver disease. Therefore, understanding the molecular mechanisms underlying the function of this receptor is essential for the development of new therapies to treat these diseases.

Source

Rabbit

Specificity

The generation of this VLDLR antibody involves rabbits being immunized with a synthetic peptide conjugated with KLH. This peptide is sourced from the Central region of the human VLDLR and encompasses amino acids 484-510. To ensure a similar content is created, I'll rearrange the information accordingly.

Species Reactivity

Human

Predictive reaction species

Rb

Application

FC~~1:25
IHC-P~~1:10~50
WB~~1:1000

Properties

Clonality

Polyclonal Antibody

Isotype

Rabbit Ig

Stability & Storage

To ensure optimal storage conditions, it is recommended to maintain the sample refrigerated between 2-8°C for a maximum of 2 weeks. If a longer shelf life is desired, it is advisable to store the sample at -20°C in small volumes to avoid any potential freeze-thaw cycles. This will help maintain the integrity of the sample and ensure that it remains viable for further analysis or experimentation. Proper storage of the sample is crucial to ensure accurate and reliable results, so it is important to follow these guidelines carefully.

Storage buffer

The antibody provided is a purified polyclonal antibody that comes in PBS solution containing 0.09% (W/V) sodium azide as a preservative. It has undergone purification using a protein A column, and subsequent peptide affinity purification to ensure high quality.

Research area

Cancer is a complex disease that affects various parts of the body, including the cardiovascular system, metabolism, and neuroscience. One of the crucial factors in understanding cancer is signal transduction, which refers to the process of cellular communication and how it influences the development and progression of cancer.
In cancer, abnormal signal transduction pathways can lead to uncontrolled cell growth, invasion, and metastasis. These pathways are often dysregulated in cancer cells, leading to alterations in key cellular processes such as proliferation, survival, and differentiation.
The cardiovascular system is also significantly affected by cancer. Certain types of cancer can directly impact the heart and blood vessels, leading to conditions such as cardiomyopathy, arrhythmias, and thrombosis. Additionally, cancer treatments, such as chemotherapy and radiation therapy, can have detrimental effects on the cardiovascular system.
Metabolism plays a crucial role in cancer development and progression. Cancer cells exhibit altered metabolic pathways, promoting the utilization of glucose and other nutrients to support their rapid growth and proliferation. This metabolic reprogramming is not only essential for meeting the energy demands of cancer cells but also contributes to the survival and evasion of the immune system by cancer cells.
Neuroscience, the study of the nervous system, is also interconnected with cancer. The nervous system plays a role in the regulation of tumor growth and progression. Additionally, cancer can affect the nervous system, leading to neurological symptoms and complications.
Understanding the intricate connections between cancer, cardiovascular health, metabolism, neuroscience, and signal transduction is crucial for developing effective strategies for cancer prevention, diagnosis, and treatment. Targeting specific signaling pathways involved in cancer, modulating metabolic reprogramming, and considering the cardiovascular and neurological effects of cancer and its treatments are important areas of research in the fight against cancer.

Target

Background

The transport of VLDL into cells is facilitated by its binding to a receptor and subsequent internalization through endocytosis. To initiate this process, the receptor-ligand complexes need to form clusters within clathrin-coated pits. Reelin binding triggers the phosphorylation of Dab1 and the modulation of Tau phosphorylation, demonstrating a similarity in their signaling pathways. By rearranging the provided content, we can produce a highly similar version that is based on the original text information.

Celluar localization

Protein located in the membrane; Type I membrane protein that passes through the membrane only once. Found in the clathrin-coated pit in the membrane; Single-pass type I membrane protein. Try rearranging the words!"

UniPort

P98155

References

References

Sakai, K., et al. Brain Res. 1276, 11-21 (2009)
Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)
Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)
Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)