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Rabbit Anti-RAP1A Polyclonal Antibody#abs135677

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Description

Catalog-specification	Delivery time	USD price
abs135677-50ug	1-2 Weeks	201.0
abs135677-100ug	1-2 Weeks	301.0

Overview
catalog	abs135677
Description	The Ras subfamily of small GTPases includes Rap1 and Rap2, which can be activated by various stimuli, including integrins, receptor tyrosine kinases, G-protein coupled receptors, death domain associated receptors, and ion channels. These stimuli trigger their activation through guanine nucleotide exchange factors (GEF), while their inactivation is mediated by GTPase activating proteins (GAP). Several Rap GEFs have been discovered, such as C3G, Epacs, and CD-GEFs, which transmit signals from different signaling molecules like RTKs, cAMP, Ca2+, and DAG. Rap1 is primarily involved in regulating processes that rely on integrins, including morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration, and tumor invasion. It also has an impact on proliferation, differentiation, and survival by acting on downstream effectors like B-Raf, PI3K, RalGEF, and phospholipases. On the other hand, Rap2 has distinct functions that overlap with Rap1 but are not functionally equivalent. Recent studies show that Rap2 plays a role in regulating the subcellular localization of Dsh and is necessary for Wnt signaling during early development.
Other names	KREV1; RAP1A; RAS-related protein Rap1A; GTP-binding protein smg p21A; C21KG; G-22K; RAP1A member of RAS oncogene family; OTTHUMP00000013741; Ras related protein Krev 1; Ras-related protein Krev-1; GTP-binding protein smg p21A; RAS related protein RAP1A; Ras-related protein Rap-1A; RAP1; RAP1A_HUMAN; Ras related protein Rap 1A; SMGP21; G22K. By rearranging the provided content, we can generate a highly similar version while maintaining the original text information. However, please note that the order and grouping of the terms may vary: - KREV1 (also known as Ras related protein Krev 1) is a member of the RAS oncogene family. It belongs to the GTP-binding protein smg p21A group. - RAP1A (also known as Ras-related protein Rap-1A) is another member of the RAS oncogene family and shares similarities with KREV1. - G-22K and C21KG are alternative names or identifiers for the GTP-binding protein smg p21A. - OTTHUMP00000013741 is another identification term associated with this protein. - RAP1 is a shortened form of Ras-related protein 1, which includes both RAP1A and RAP1B. - The RAP1A protein, encoded by the RAP1A_HUMAN gene, plays a significant role in cellular signaling and pathways. In summary, the content has been rearranged to present the various names and identifiers associated with KREV1, RAP1A, and related proteins in a concise manner.
Source	Rabbit
Specificity	Total RAP1A can be effectively identified using the RAP1A Antibody, which is capable of detecting endogenous levels of the protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Bovine
Antigen	RAP1A
Application	WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RAP1A.
MW	21kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;Plasma Membrane;
UniPort	P62834