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Rabbit Anti-CD209 Polyclonal Antibody#abs132692

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Description

Catalog-specification	Delivery time	USD price
abs132692-50ug	1-2 Weeks	201.0
abs132692-100ug	1-2 Weeks	301.0

Overview
catalog	abs132692
Description	The immature dendritic cells (DCs) express a pathogen-recognition receptor on their surface, which plays a crucial role in initiating the primary immune response. This receptor is responsible for recognizing and internalizing pathogens, leading to their degradation in lysosomal compartments. Afterward, the receptor is recycled to the cell membrane surface, presenting pathogen-derived antigens to resting T-cells via MHC class II proteins. This presentation is essential for triggering the adaptive immune response. This recognition process is believed to rely on the specific binding of high mannose N-linked oligosaccharides found in various pathogen antigens. Some examples of these antigens include HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM, and Lewis-x antigen in Schistosoma mansoni SEA. In summary, the pathogen-recognition receptor expressed on immature DCs is critical for the early detection and capture of pathogens. By presenting pathogen-derived antigens to T-cells, it triggers the adaptive immune response, ultimately contributing to the body's defense against infections.
Other names	C-type lectin domain family 4 member L, also known as CD209 or DC-SIGN, is a protein that plays an important role in the immune system. It belongs to the C-type lectin superfamily and is expressed on the surface of certain types of immune cells, particularly dendritic cells. CD209 is involved in the recognition and uptake of pathogens, including viruses and bacteria, by dendritic cells. It binds to a variety of carbohydrate structures on the surface of these pathogens, allowing the dendritic cells to phagocytize and process them for presentation to other immune cells. Mutations in CD209 have been associated with increased susceptibility to certain viral infections, such as dengue fever. However, CD209 has also been shown to confer protection against HIV infection, as it can bind to and neutralize the virus. Overall, CD209 is an important protein in the immune response, playing a crucial role in the recognition and clearance of pathogens.
Source	Rabbit
Specificity	The CD209 antibody is capable of detecting the total levels of endogenous CD209 in a sample. To rephrase this information, one could say that the CD209 antibody is effective in identifying the overall concentration of CD209 that naturally occurs within a specimen.
Species Reactivity	Human;Mouse
Antigen	CD209
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	44 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
Tissue specificity	Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9NNX6