Rabbit Anti-CD226/DNAM-1 Polyclonal Antibody #abs130035

abs130035-50ug

1-2 Weeks

201

abs130035-100ug

1-2 Weeks

301

Description

The interaction between the DNAM-1 receptor and its ligands is crucial for various cellular processes such as intercellular adhesion, lymphocyte signaling, cytotoxicity, and lymphokine secretion. This receptor is predominantly expressed in cytotoxic T-lymphocytes (CTL) and natural killer (NK) cells. Notably, DNAM-1 interacts with two ligands, namely PVR and PVRL2, to carry out its diverse functions. The significance of DNAM-1 lies in its ability to mediate crucial immune responses and facilitate communication between cells. By rearranging the presented information, we can emphasize the importance of the DNAM-1 receptor and its role in cell interactions and immune function.

Other names

The CD226 molecule, also known as DNAM-1 or DNAX accessory molecule 1, is an adhesion glycoprotein and a platelet and T cell activation antigen. It is also referred to as CD226 antigen, CD226_HUMAN, PTA1, or T lineage specific activation antigen 1 antigen. CD226 plays a crucial role in immune system activation and cell-to-cell interactions. This multi-functional molecule is involved in various biological processes and is of great interest in immunology research. Further understanding its function and mechanisms can potentially lead to advancements in disease diagnosis and treatment.

Source

Rabbit

Specificity

The endogenous levels of total CD226/DNAM-1 can be detected using the CD226/DNAM-1 antibody. Please rearrange the content in a highly similar manner, ensuring that the meaning remains based on the original information.

Species Reactivity

Human;Mouse

Application

To ensure accurate results, we recommend using a dilution of 1:500 to 1:3000 for Western Blotting, and a dilution of 1:100 to 1:500 for Immunofluorescence/Immunocytochemistry. For ELISA with peptide antigens, we suggest a dilution range of 1:20000 to 1:40000. It is important to note that adjusting the dilution may be necessary based on the specific samples being tested.

Immunogen

A peptide has been synthesized using human CD226/DNAM-1 as the source material. This peptide is designed to mimic the properties of the original protein, allowing it to interact with other molecules in a similar way. The resulting product is highly similar to the original protein, making it an ideal candidate for use in research and therapeutics. By utilizing the natural properties of CD226/DNAM-1, scientists have created a powerful tool that has the potential to advance the field of biomedical science and improve human health.

Properties

Concentration

1mg/ml

Purification

Through the process of peptide affinity chromatography utilizing SulfoLink™ Coupling Resin, we were able to effectively purify the antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is advisable to store it at a temperature below -20 °C for a year. It is important to avoid thawing and refreezing the product repeatedly as this may compromise its effectiveness.

Storage buffer

The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4. It should be stored at -20 °C with a solution containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for 12 months from the date of receipt. It is important to adhere to these storage guidelines to ensure the integrity and effectiveness of the product.

Target

Background

Regulating intercellular adhesion, lymphocyte signaling, cytotoxicity, and lymphokine secretion, this protein plays a crucial role in cytotoxic T-lymphocyte (CTL) and natural killer (NK) cell activities (PubMed:8673704). It acts as a cell surface receptor for NECTIN2 and, upon binding to its ligand, triggers T-cell growth and the production of various cytokines such as IL2, IL5, IL10, IL13, and IFNG. Interestingly, it competes with PVRIG for binding to NECTIN2 (PubMed:26755705).

Tissue specificity

Expressed by peripheral blood T-lymphocytes.

Celluar localization

Plasma Membrane;

UniPort

Q15762