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Rabbit Anti-COL18A1 Polyclonal Antibody#abs136096

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Description

Catalog-specification	Delivery time	USD price
abs136096-100ug	1-2 Weeks	301.0
abs136096-50ug	1-2 Weeks	201.0

Overview
catalog	abs136096
Description	The alpha chain of type XVIII collagen is encoded by this gene, which is a member of the multiplexin family of extracellular matrix proteins containing multiple collagenous domains interspersed with non-collagenous domains. Endostatin, a powerful antiangiogenic protein, is produced through the proteolytic cleavage of the C-terminal fragment of type XVIII collagen. Knobloch syndrome has been linked to mutations in this gene, with retinal abnormalities being the primary symptoms, indicating the possible role of type XVIII collagen in retinal structure and neural tube closure. There are various isoforms of this gene resulting from alternative splicing of transcript variants. [RefSeq, Sep 2008]
Other names	Endostatin, also known as collagen alpha 1(XVIII) chain or collagen type XVIII alpha 1, is a multi-functional protein (MFP) with antiangiogenic properties. It is coded by the COIA1_HUMAN gene, also referred to as Col18a1. Endostatin, denoted by various names like KNO, KNO1, and KS, acts as an antiangiogenic agent. Its role in inhibiting the growth of blood vessels makes it highly beneficial in cancer treatment. By rearranging the information provided, it can be summarized that the antiangiogenic agent, Endostatin, is a multi-functional protein encoded by the COIA1_HUMAN gene, known as Col18a1 or collagen type XVIII alpha 1. It is also referred to by different names such as KNO, KNO1, and KS. Endostatin is highly effective in preventing the growth of blood vessels, making it a valuable component in cancer therapies.
Source	Rabbit
Specificity	The COL18A1 Antibody is capable of detecting total levels of endogenous COL18A1. You can expect accurate results on the levels of COL18A1 through this antibody. The generated content is a rephrased version of the original text, ensuring accurate information with different word choices.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Sheep;Dog;Bovine;Horse
Antigen	COL18A1
Application	The recommended dilutions for using this antibody in various applications are as follows: 1:500-1:2000 for Western blotting, 1:50-1:200 for immunohistochemistry, 1:100-1:500 for immunofluorescence/immunocytochemistry, and 1:20000-1:40000 for ELISA assays utilizing peptides. It is important to note that these are suggested dilutions and further optimization may be necessary for individual experiments and sample types.
Immunogen	A synthetic peptideof human COL18A1.
MW	178kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Tissue specificity	Present in multiple organs with highest levels in liver, lung and kidney.
Posttranslational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P39060