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Rabbit Anti-IL1F5 Polyclonal Antibody#abs132902

Please note that the price mentioned here is only for your reference. For detailed pricing information, we suggest that you get in touch with our seller, Vecent. Western blot analysis of IL1F5 expression in Transfected 293T cell lysate ,The lane on the left is treated with the antigen-specific...

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Description

Catalog-specification	Delivery time	USD price
abs132902-100ug	1-2 Weeks	301.0
abs132902-50ug	1-2 Weeks	201.0

Please note that the price mentioned here is only for your reference. For detailed pricing information, we suggest that you get in touch with our seller, Vecent.

Overview
catalog	abs132902
Description	An antagonist that is highly specific to IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9) has been identified. This antagonist is believed to play a crucial role in an alternate signaling system akin to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which are present in epithelial barriers and participate in local inflammatory response. This new antagonist is expected to provide valuable insights into the complex mechanisms underlying inflammation and may lead to the development of novel therapeutics aimed at targeting this pathway.
Other names	This is a list of various names for interleukin 1 delta, a member of the interleukin 1 family. These include FIL1, FIL1 delta, IL 1 delta, IL 1F5, IL 1HY1, IL 1L1, IL 1RP3, and IL-1-related protein 3. Other names include IL-1ra homolog, IL1F5a, IL-1HY1, Interleukin 36 receptor antagonist, and PSORP. It is also identified by the gene names FIL1D, Fil1delta, I36RA_HUMAN, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, IL36RN, MGC29840, and RP23-176J12.6. This cytokine is involved in the inflammatory response and may play a role in various disease processes such as psoriasis. Understanding the different names and gene codes associated with this protein is important for research and therapeutic development.
Source	Rabbit
Specificity	The IL1F5 antibody can identify total IL1F5 levels that exist in the body naturally. To create similar content, the information from the original text could be rearranged to read as follows: The total IL1F5 present in the body can be detected using the IL1F5 antibody. This antibody identifies endogenous levels of IL1F5 accurately.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit
Antigen	IL1F5
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	17 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Tissue specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Celluar localization	Extracellular region or secreted;
UniPort	Q9UBH0