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Rabbit Anti-IL1F6 Polyclonal Antibody#abs132903

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Description

Catalog-specification	Delivery time	USD price
abs132903-100ug	1-2 Weeks	301.0
abs132903-50ug	1-2 Weeks	201.0

Overview
catalog	abs132903
Other names	Interleukin 1 epsilon, also known as FIL1 or IL1F6, is a protein belonging to the interleukin 1 family. It is encoded by the IL1F6 gene and is commonly referred to as IL1RP2. IL1 epsilon plays a crucial role in immune regulation and inflammation. With various aliases such as FIL1E, IL-1 epsilon, or IL-1F6, this protein exhibits significant similarities to IL36A, another member of the interleukin 1 family. It is worth mentioning that IL1 epsilon has been associated with multiple functional annotations like MGC129552, MGC129553, MGC151479, MGC151481, OTTMUSP00000012798, and RP23-176J12.4. Its importance in biological processes and potential therapeutic applications makes it a compelling subject of study.
Source	Rabbit
Specificity	The IL1F6 antibody is capable of identifying the total IL1F6 protein present in an organism. The antibody has the ability to detect endogenous levels of the protein accurately. This means that it is capable of measuring the naturally occurring amount of IL1F6 in an organism without the need for any external stimulus that may alter its levels. Overall, the IL1F6 antibody is a reliable tool for researchers seeking to study this particular protein and its functions.
Species Reactivity	Human;Mouse
Antigen	IL1F6
Application	For Western blotting, the recommended dilution range is from 1:500 to 1:2000. For immunohistochemistry, the suggested dilution range is from 1:50 to 1:200. For ELISA using peptides, the appropriate dilution range is from 1:20000 to 1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results in your experiments. Always refer to the manufacturer's instructions for specific details and protocols.
Immunogen	A synthesized peptide.
MW	25 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. It was an effective method that produced a highly purified and concentrated antiserum, ideal for its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to multiple freeze/thaw cycles as it may compromise its quality.
Storage buffer	75%、7.4 pH，IgG、150mM0.02%。
Target
Background	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.
Tissue specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.
Posttranslational modification	N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
Celluar localization	Extracellular region or secreted;
UniPort	Q9UHA7