Rabbit Anti-IL1F8 Polyclonal Antibody#abs132904
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Description
| Catalog-specification | Delivery time | USD price |
abs132904-100ug | 1-2 Weeks | 301.0 |
abs132904-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned is purely for your reference. For detailed pricing information, please get in touch with our seller Vecent. Kindly note that the generated content should be based on the original information provided and not created using the same tone or language as ChapGPT. We expect the content to be unique and different in style and language.
| Overview | |
catalog | abs132904 |
| Other names | The gene 2310043N20Rik belongs to the family of interleukin 1 eta, also known as FIL1 (ETA). This gene is responsible for coding several protein products, including FIL1, FIL1 eta, FIL1H, FILI-(ETA), IL 1F8, IL 1H2, IL-1 eta, IL-1F8, IL-1H2, IL1 ETA, and IL1F8a. The protein encoded by this gene is a member of the interleukin 1 family and is involved in several biological activities, including inflammation, cell proliferation, and differentiation. Additionally, 2310043N20Rik is also referred to as IL36B, MGC126880, MGC126882, OTTMUSP00000012797, RP23-176J12.1, and Interleukin-1 family member 8. Its canonical product is IL 1F8a, and it is also known as Interleukin 1 homolog 2, Interleukin 1 Superfamily e, and Interleukin 36 beta. In summary, the gene 2310043N20Rik is a member of the interleukin 1 eta family and codes for several protein products with varying biological activities. It is also known by several other names, including IL36B and Interleukin-1 family member 8. |
| Source | Rabbit |
| Specificity | Total IL1F8 can be detected by the IL1F8 antibody at endogenous levels. |
| Species Reactivity | Human;Mouse |
| Antigen | IL1F8 |
| Application | Below are the rearranged versions based on the original text information: - The dilution range for Western Blot is 1:500 to 1:2000. - For Immunohistochemistry, the recommended dilution range is 1:50 to 1:200. - In ELISA using a peptide, the suggested dilution range is 1:20000 to 1:40000. Please note that the rearranged content is still conveying the same information as the original text but in a slightly different order. |
| Immunogen | A synthesized peptide. |
| MW | 17 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure optimal storage conditions, it is recommended to store the product at -20 °C for a period of one year. It is crucial to avoid subjecting the product to repeated freeze-thaw cycles. |
| Storage buffer | IgG，pH7.4，150mM NaCl，0.02%50%。 |
Target | |
Background | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. |
| Tissue specificity | Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. |
| Posttranslational modification | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). |
| Celluar localization | Extracellular region or secreted; |
| UniPort | Q9NZH7 |
Western blot analysis of IL1F8 expression in A549 cell lysate with blocking peptide,The lane on the left is treated with the antigen-specific peptide.
This product is for research use only, not for use in diagnostic prodecures or in human.
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