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Rabbit Anti-SRD5A2 Polyclonal Antibody#abs137893

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Description

Catalog-specification	Delivery time	USD price
abs137893-100ug	1-2 Weeks	301.0
abs137893-50ug	1-2 Weeks	201.0

Overview
catalog	abs137893
Other names	Steroid 5-alpha reductase 2, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 2, is an enzyme that plays a key role in the synthesis of androgens. It is encoded by the SRD5A2 gene and belongs to the steroid 5-alpha reductase family. This enzyme catalyzes the conversion of testosterone into dihydrotestosterone (DHT), which is a more potent androgen. The SRD5A2 gene is located on chromosome 2p23 and mutations in this gene have been linked to micropenis and other abnormalities of the external genitalia. The enzyme has been targeted by pharmaceutical companies in the development of drugs for the treatment of androgenic disorders such as benign prostatic hyperplasia (BPH) and androgenic alopecia (AGA). Despite its importance in androgen physiology, the expression, regulation, and physiological function of SRD5A2 remain poorly understood. However, ongoing research is expected to shed more light on this critical enzyme.
Source	Rabbit
Specificity	The SRD5A2 Antibody has the ability to detect the total levels of endogenous SRD5A2. This means that it can identify and measure the amount of SRD5A2 present in a given sample. The detection of SRD5A2 is important in various research and diagnostic applications, as it is a crucial enzyme involved in the synthesis of androgens. By detecting the levels of SRD5A2, researchers and clinicians can gain insights into the regulation of androgen synthesis and its potential role in various physiological and pathological conditions.
Species Reactivity	Human
Antigen	SRD5A2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SRD5A2.
MW	28 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. By rearranging the provided content, a highly similar version is generated while maintaining the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple cycles of freezing and thawing.
Storage buffer	This rabbit IgG comes in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol included. It is recommended that you store it at a temperature of -20°C, and it should remain stable for up to 12 months from the date you receive it.
Target
Background	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Tissue specificity	Expressed in high levels in the prostate and many other androgen-sensitive tissues.
Celluar localization	Endoplasmic reticulum;
UniPort	P31213