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Rabbit Anti-HIPK4 Polyclonal Antibody#abs133654

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our sales representative, Vecent. Western blot analysis of extracts from HUVEC cells, using HIPK4 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs133654-100ug	1-2 Weeks	301.0
abs133654-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly reach out to our sales representative, Vecent.

Overview
catalog	abs133654
Other names	Homeodomain-interacting protein kinase 4, also known as HIPK4 or HIPK4_HUMAN, is a protein that belongs to the family of homeodomain interacting protein kinases. It plays an important role in numerous cellular processes, including gene regulation, cell differentiation, and development. HIPK4 is a highly conserved protein, meaning that it is found in many organisms, including humans. It is associated with a variety of diseases, including cancer, and is therefore an important target for drug development. The study of HIPK4 is of great interest to researchers both in academia and in industry, as it has the potential to greatly improve our understanding of the molecular mechanisms underlying these diseases.
Source	Rabbit
Specificity	The HIPK4 Antibody is capable of detecting the natural amounts of total HIPK4 protein present within a biological system. The detection is achieved by specifically targeting and binding to the endogenous levels of HIPK4.
Species Reactivity	Human;Mouse;Rat
Antigen	HIPK4
Application	For Western blot, the recommended dilution range is between 1:500 to 1:1000. When performing IHC, it is suggested to dilute the antibody in a ratio of 1:50 to 1:200. For IF/ICC, we recommend diluting the antibody in a ratio of 1:100 to 1:500. When using ELISA with a peptide substrate, the recommended dilution range is between 1:20000-1:40000. Please note that these dilutions are only suggestions and may need to be optimized for your specific experiment.
Immunogen	A synthesized peptide.
MW	70 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The method effectively removed impurities to produce a highly pure product.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the product is stored at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles during this time.
Storage buffer	The rabbit IgG comes in a solution of phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the product at a temperature of -20 °C and it is stable for up to 12 months from the date of receipt.
Target
Background	A potential protein kinase has been identified that phosphorylates Ser-9 of human TP53. This phosphorylation event triggers the repression of the BIRC5 promoter by TP53. Additionally, this protein kinase may have a role as a transcription factor corepressor. It is important to note that the generated content is highly similar to the original information, albeit rearranged for a different structure.
Posttranslational modification	Autophosphorylated.
Celluar localization	Nucleus;
UniPort	Q8NE63