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Rabbit Anti-ACRBP Polyclonal Antibody#abs133655

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Description

Catalog-specification	Delivery time	USD price
abs133655-100ug	1-2 Weeks	301.0
abs133655-50ug	1-2 Weeks	201.0

Overview
catalog	abs133655
Other names	The human protein ACRBP, also known as acrosin binding protein, is a precursor to the acrosin-binding protein that plays a crucial role in fertilization. Another name for ACRBP is Cancer/testis antigen 23, or CT23. It is also referred to as Cancer/testis antigen OY TES 1 or OY-TES-1. The FLJ51160 gene encodes for this protein. ACRBP specifically binds to proacrosin, a protease enzyme found in spermatozoa, and inhibits its activity. This ensures that proacrosin remains inactive until it reaches the egg where it will be needed for fertilization. SP32 is the alternate name for proacrosin-binding protein sp32, which is another protein found to bind to proacrosin. Understanding the molecular mechanisms behind fertilization is critical for developing approaches to regulate fertility. Consequently, researchers have been studying ACRBP and SP32 closely to identify their roles in reproduction. As a result, these proteins have garnered interest for their potential use in various therapeutic applications.
Source	Rabbit
Specificity	The ACRBP Antibody is capable of detecting total ACRBP levels that are naturally present within the body. This means that researchers can use this antibody to gain insight into the behavior of ACRBP within the body without having to artificially manipulate its levels.
Species Reactivity	Human;Rat
Antigen	ACRBP
Application	Sure, here's a rearranged version of the content: For western blotting (WB), the recommended dilution range is typically between 1:500 and 1:1000. For immunofluorescence (IF) or immunocytochemistry (ICC), a dilution of 1:100 to 1:500 is commonly used. When it comes to enzyme-linked immunosorbent assay (ELISA) using peptides as antigens, the optimal dilution range is usually between 1:20000 and 1:40000. It's important to follow these dilution guidelines to ensure accurate and reliable results in the respective techniques.
Immunogen	A synthesized peptide.
MW	61 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography for purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Make sure to keep this product at a temperature of -20 °C for a duration of one year. It's important to refrain from subjecting it to repeated cycles of freezing and thawing.
Storage buffer	The Rabbit IgG solution is formulated in a phosphate buffered saline with pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this solution at a temperature of -20°C, as it remains stable for up to 12 months from the date of receipt.
Target
Background	May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.
Tissue specificity	Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
Posttranslational modification	The N-terminus is blocked.Phosphorylated on Tyr residues in capacitated sperm.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	Q8NEB7