Rabbit Anti-PPARG Polyclonal Antibody#abs135593
Please be advised that the price mentioned above is provided solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. It is important to note that the content generated will be vastly different from the original text, as it will...
Description
| Catalog-specification | Delivery time | USD price |
abs135593-50ug | 1-2 Weeks | 201.0 |
abs135593-100ug | 1-2 Weeks | 301.0 |
Please be advised that the price mentioned above is provided solely for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. It is important to note that the content generated will be vastly different from the original text, as it will not adhere to the dialogue method used by ChapGPT.
| Overview | |
catalog | abs135593 |
Description | Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor within the superfamily. Its primary function involves transcriptional activation. PPARγ is mainly expressed in adipocytes, vascular smooth muscle cells, and macrophages. Additionally, it plays a crucial role in adipogenesis, lipid metabolism, insulin sensitivity, cell proliferation, and inflammation. To regulate PPARγ transcriptional activity, its phosphorylation at Ser84 by MAP kinase inhibits its functionality. |
| Other names | Peroxisome proliferator-activated receptor gamma (PPARgamma), also known as nuclear receptor subfamily 1 group C member 3 (NR1C3), is a transcription factor involved in adipogenesis and glucose metabolism. It has two isoforms, PPARG1 and PPARG2, and is encoded by the PPARG gene. Other names for PPARgamma include Peroxisome proliferator activated receptor gamma variant 1, CIMT1, GLM1, and OTTHUMP00000185032 and OTTHUMP00000185036. PPARgamma is a critical regulator of adipocyte differentiation and lipid metabolism and is a target for the treatment of metabolic disorders such as type 2 diabetes and obesity. It plays a key role in maintaining glucose homeostasis, insulin sensitivity, and lipid metabolism in adipose tissue, liver, and muscle. In conclusion, PPARgamma is a transcription factor that is essential for regulating adipogenesis and glucose metabolism. It plays a crucial role in maintaining metabolic homeostasis and is a therapeutic target for various metabolic disorders. |
| Source | Rabbit |
| Specificity | The total expression of PPARG can be detected by the PPARG Antibody, which specifically targets the endogenous levels of this protein. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | PPARG |
| Application | ELISA(peptide) 1:20000-1:40000, WB 1:500-1:1000, IHC 1:50-1:100, IF/ICC 1:100-1:500 are the recommended dilutions for different assay techniques. This information can guide researchers in optimizing the dilution ratios for their specific experimental needs. It is important to note that these dilutions may vary depending on the target antigen, antibody specificity, and experimental conditions. Therefore, researchers should perform preliminary experiments to determine the optimal dilution range for their particular assay. |
| Immunogen | N term -peptide of human PPARG. |
| MW | 58kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a purified antiserum, the SulfoLink™ Coupling Resin was employed for peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). |
| Tissue specificity | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
| Posttranslational modification | O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity). |
| Celluar localization | Cytosol;Nucleus; |
| UniPort | P37231 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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