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Rabbit Anti-NIP7 Polyclonal Antibody#abs138658

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Description

Catalog-specification	Delivery time	USD price
abs138658-100ug	1-2 Weeks	301.0
abs138658-50ug	1-2 Weeks	201.0

Overview
catalog	abs138658
Other names	The protein known as NIP7 homolog is involved in the biogenesis of the ribosome subunit and plays an essential role in pre-rRNA processing in the nucleolus. It is also referred to as CGI37, FLJ10296, HSPC031, HSPC180, KD93, and Nuclear import 7 homolog across different contexts. This protein is conserved throughout evolution, with homologs present in both prokaryotic and eukaryotic cells. In humans, it is a highly conserved protein, and mutations in NIP7 have been linked to various diseases. NIP7 is critical in transporting proteins across the nuclear membrane and has been identified as a component of several complexes involved in RNA metabolism. It is known to interact with various ribosomal proteins and other auxiliary factors necessary for pre-rRNA processing. In summary, NIP7 is a nuclear protein that plays a crucial role in ribosome subunit biogenesis and pre-rRNA processing. It is conserved throughout evolution and interacts with various other proteins and complexes involved in RNA metabolism. Mutations in NIP7 have been linked to various diseases in humans.
Source	Rabbit
Specificity	The NIP7 Antibody has the ability to recognize and bind to total NIP7 that naturally occurs within a cell. This antibody is useful in detecting endogenous levels of NIP7.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	NIP7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NIP7.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, peptide affinity chromatography was utilized to purify the antiserum. This process allowed for the isolation of a highly purified and refined product with excellent specificity and quality.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage is recommended at -20 °C to maintain the quality of the product. It is crucial to avoid exposing the product to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4. It also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it should be stored at a temperature of -20 °C. The product is guaranteed to remain stable for a period of 12 months from the date of receipt.
Target
Background	Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
Tissue specificity	Expressed in hematopoietic stem/progenitor cells.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9Y221