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Rabbit Anti-INPP5E Polyclonal Antibody#abs138659

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Description

Catalog-specification	Delivery time	USD price
abs138659-100ug	1-2 Weeks	301.0
abs138659-50ug	1-2 Weeks	201.0

Overview
catalog	abs138659
Other names	The 72 kDa inositol polyphosphate 5-phosphatase, also known as INP5E_HUMAN, is an enzyme that plays a crucial role in the regulation of cellular signaling pathways. It is responsible for the hydrolysis of phosphoinositides, specifically phosphatidylinositol (4,5) bisphosphate, to generate inositol 1,4,5-trisphosphate and diacylglycerol. This enzyme is encoded by the INPP5E gene and belongs to the phosphatidylinositol polyphosphate 5-phosphatase type IV family. It is also commonly referred to as phosphatidylinositol polyphosphate 5 phosphatase or PPI5PIV. The activity of this enzyme is important in various cellular processes, including cell growth, differentiation, and proliferation. It is also involved in the regulation of intracellular vesicle trafficking, which is essential for proper cellular function. Mutations in the INPP5E gene have been linked to a number of diseases, such as Joubert syndrome, MORM syndrome, and autism spectrum disorders. Therefore, the study of this enzyme and its function is critical in understanding the molecular mechanisms underlying these disorders and the development of potential therapies.
Source	Rabbit
Specificity	The INPP5E Antibody has the ability to identify the total amount of INPP5E that exists naturally within the body. This means that the antibody is capable of detecting the endogenous levels of INPP5E accurately. To create content that closely resembles this information, one could rearrange the phrasing and structure slightly, but maintain the key points. For example: "The total amount of endogenous INPP5E can be detected using the INPP5E Antibody, which is able to identify and measure this protein in the body with high accuracy."
Species Reactivity	Human;Mouse;Rat
Antigen	INPP5E
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human INPP5E.
MW	70 kDa
Properties
Concentration	1mg/ml
purification	To obtain purified antiserum, peptide affinity chromatography was performed using SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product quality, it is recommended to keep the item in a freezer set at -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	This product is composed of Rabbit IgG diluted in phosphate buffered saline (pH 7.4) with a concentration of 150mM NaCl. To ensure stability and prevent bacterial growth, it also contains 0.02% sodium azide and 50% glycerol. It should be stored at a temperature of -20 °C. Please note that the product remains stable for a period of 12 months from the date of receipt.
Target
Background	Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Tissue specificity	Detected in brain, heart, pancreas, testis and spleen.
Celluar localization	Cytoskeleton;Cytosol;Golgi apparatus;Plasma Membrane;
UniPort	Q9NRR6