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Rabbit Anti-SRRM2 Polyclonal Antibody#abs138409

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Description

Catalog-specification	Delivery time	USD price
abs138409-100ug	1-2 Weeks	301.0
abs138409-50ug	1-2 Weeks	201.0

Overview
catalog	abs138409
Other names	Serine/arginine-related nuclear matrix protein of 300 kDa is also known as CWC21, KIAA0324, SRm300, SRL300, SRRM2, and TaxREB803. This splicing coactivator subunit is an essential component of the nuclear matrix and plays a crucial role in the regulation of pre-mRNA splicing. The 300 kDa nuclear matrix antigen is rich in serine and arginine residues, making it highly repetitive. It is a member of the SR protein family and is involved in various processes, including transcription, RNA processing, and nuclear mRNA export. SRRM2 has been associated with a variety of diseases, including cancer, and is a promising target for therapeutic intervention.
Source	Rabbit
Specificity	The SRRM2 Antibody is capable of detecting total levels of endogenous SRRM2. This means that the antibody can recognize and bind to the full amount of SRRM2 that naturally occurs within a sample.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;
Antigen	SRRM2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SRRM2.
MW	300kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain product quality, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles as this may cause degradation.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.
Tissue specificity	Expressed in liver, placenta, and white blood cells.
Celluar localization	Nucleus;
UniPort	Q9UQ35