Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-RNF6 Polyclonal Antibody#abs138410

Description

Catalog-specification	Delivery time	USD price
abs138410-100ug	1-2 Weeks	301.0
abs138410-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference purposes only. For detailed pricing information, please get in touch with our sales representative Vecent. It's important to bear in mind that the content generated here should be highly similar to the original text, but it should be rephrased in a new way using a language model. We don't want to simply produce a dialogue like ChapGPT but instead offer a completely unique style of speaking.

Overview
catalog	abs138410
Other names	RNF6, also known as E3 ubiquitin-protein ligase RNF6, is a ring finger protein (C3H2C3 type) that plays an important role in protein degradation. It belongs to the RING H2 protein family and is encoded by the RNF6 gene. RNF6 is associated with various cellular processes, including cell cycle regulation, transcriptional activation, and DNA repair. This protein acts as an E3 ligase, which means it adds a small protein called ubiquitin to target proteins, marking them for degradation by the proteasome. RNF6 has been implicated in the regulation of several signaling pathways, such as Wnt, TGF-beta, and Notch pathways, by targeting specific proteins for degradation. RNF6 has also been linked to human diseases and disorders. Mutations in the RNF6 gene have been associated with hereditary spastic paraplegia type 2 (SPG2), a neurodegenerative disorder characterized by progressive weakness and spasticity of the lower limbs. In conclusion, RNF6 is an essential protein involved in protein degradation and regulation of various cellular processes. Its dysregulation can lead to the development of diseases like SPG2. Further research on RNF6 and its molecular mechanisms may provide insights into therapeutic targets for related disorders.
Source	Rabbit
Specificity	Total endogenous levels of RNF6 are detected by the RNF6 antibody. I can generate a highly similar content by rearranging the information in the original text.
Species Reactivity	Human
Antigen	RNF6
Application	，WB1:1000-3000，IF/ICC1:100-1:500，(ELISA，)1:20000-1:40000。
Immunogen	A synthesized peptide derived from human RNF6.
MW	78kda
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum went through peptide affinity chromatography for purification. To ensure its quality, it underwent rigorous processing to attain high purification standards. The final output is a purified antiserum that can effectively neutralize the targeted antigen.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it should be stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze and thaw cycles, as this may compromise its stability and efficacy. Proper storage conditions are essential to ensure that the product retains its optimum quality and potency. Therefore, it is recommended that the product is kept in a cool and dry place, away from direct sunlight and moisture, to guarantee its long-term storage.
Storage buffer	This solution contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM of NaCl, 0.02% of sodium azide, and 50% of glycerol. This product should be stored at a temperature of -20 °C. It is important to note that this solution is stable for up to 12 months from the date of receipt.
Target
Background	E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Tissue specificity	Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Celluar localization	Nucleus;
UniPort	Q9Y252