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Rabbit Anti-ING3 Polyclonal Antibody#abs133016

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. We recommend reaching out to Vecent for accurate pricing details. Western blot analysis of ING3 expression in ?Humna fetal brain lysate,The lane...

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Description

Catalog-specification	Delivery time	USD price
abs133016-50ug	1-2 Weeks	201.0
abs133016-100ug	1-2 Weeks	301.0

Overview
catalog	abs133016
Other names	The gene 1300013A07Rik is also known as Eaf 4, FLJ20089, ING 2, ING 3, and MEAF4. It codes for the protein Inhibitor of Growth Family Member 3, which is commonly referred to as ING3. ING3 is a vital regulator protein that plays a critical role in inhibiting cellular growth and proliferation. The human version of ING3 is known as ING3_HUMAN. Additionally, ING3 is sometimes referred to as p47 ING3 or p47 regulator protein due to its role in regulating cellular activity. It is an essential protein that has been shown to be involved in several cellular mechanisms, making it an important target for further research and potential therapeutic interventions.
Source	Rabbit
Specificity	The ING3 antibody has the ability to recognize and bind to total ING3 at levels that are naturally present within the organism. This means that it is capable of detecting endogenous amounts of ING3, without requiring any external or manipulated sources. Overall, this antibody serves as an effective tool for studying the role and function of ING3 in various biological pathways.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	ING3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	50 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. A highly-purified antiserum product was obtained from this process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the item, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple cycles of freezing and thawing.
Storage buffer	The formulation of the solution includes rabbit IgG suspended in a buffer of phosphate buffered saline at pH 7.4. To maintain isotonicity, 150mM NaCl is added. Additionally, a small amount of sodium azide (0.02%) is included as a preservative. To aid in stability and storage, 50% glycerol is added.
Target
Background	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Tissue specificity	Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
Celluar localization	Nucleus;
UniPort	Q9NXR8