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Rabbit Anti-CCR2 Polyclonal Antibody#abs133090

Please note that the price provided is solely for your reference. To obtain the specific pricing details, kindly get in touch with our seller Vecent. Western blot analysis of CCR2 expression in Jurkat cell lysate,The lane on the left is treated with the antigen-specific peptide. This product is...

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Description

Catalog-specification	Delivery time	USD price
abs133090-50ug	1-2 Weeks	201.0
abs133090-100ug	1-2 Weeks	301.0

Please note that the price provided is solely for your reference. To obtain the specific pricing details, kindly get in touch with our seller Vecent.

Overview
catalog	abs133090
Description	This receptor plays a crucial role in recognizing and responding to the chemokines MCP-1, MCP-3, and MCP-4. Its main function is to transmit signals within the cell by elevating the concentration of calcium ions. Additionally, it serves as an alternative coreceptor to CD4 in the context of HIV-1 infection. It is important to note that the content generated should be substantially different from the original text and not follow the pattern of content generation used by ChapGPT.
Other names	This gene, known as CCR2, is responsible for the production of a type of protein called a chemokine receptor. This receptor is involved in the immune system response and plays an important role in inflammation, as it helps to attract certain types of immune cells to the site of infection or injury. The CCR2 protein is also known as CD192 and MCP1R, among other names. There are two forms of the protein, CCR2A and CCR2B, which are produced by alternative splicing of the CCR2 gene. These different forms of the protein may have slightly different functions. The CCR2 receptor is a target for certain drugs that are being developed to treat inflammatory diseases such as arthritis and multiple sclerosis.
Source	Rabbit
Specificity	Total CCR2 can be effectively detected by utilizing CCR2 antibody, which is capable of identifying the naturally occurring levels of CCR2 within the biological system.
Species Reactivity	Human;Mouse;Rat
Antigen	CCR2
Application	The dilution ranges for WB, IHC, and ELISA(peptide) are 1:500-1:2000, 1:50-1:200, and 1:20000-1:40000 respectively. It is important to use the appropriate dilution for each application to achieve optimal results. When performing a WB, the primary antibody should be diluted between 1:500 to 1:2000, while for IHC, the dilution range should be between 1:50 to 1:200. When conducting an ELISA using a peptide, the recommended dilution range is between 1:20000 to 1:40000. Proper dilution is crucial for accurate and reliable experimentation.
Immunogen	A synthesized peptide.
MW	42 kDa;
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, a peptide affinity chromatography process was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).
Tissue specificity	Expressed by monocytes and IL2-activated NK cells.
Posttranslational modification	N-glycosylated.Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P41597