Rabbit Anti-Claudin 10 Polyclonal Antibody #abs130070

abs130070-50ug

1-2 Weeks

201

abs130070-100ug

1-2 Weeks

301

Description

The claudin 10 protein is an essential component in the elimination of the intercellular space within tight junctions. Its function is not dependent on calcium and is primarily involved in cell adhesion. This protein is a member of the claudin family, which contributes to the formation and maintenance of tight junctions in various tissues.

Other names

The gene known as Claudin-10, or CLDN10, codes for a protein also called Claudin10. This protein belongs to a family of tight junction proteins that are involved in maintaining epithelial barrier integrity. CLDN10 is also known as OSPL, OSP like protein, or OSP-like protein. Another name for this protein is CPETRL3, or CPETRL 3. The HGNC identifier for this gene is 2033.

Source

Rabbit

Specificity

The Claudin 10 antibody is capable of identifying Claudin 10 at endogenous levels, detecting the total amount of the protein present in cells. This information is important for researchers studying the function of Claudin 10 and its involvement in various biological processes. By using this antibody, scientists can better understand the role of Claudin 10 in cellular activities and potentially devise new therapeutic approaches targeting this protein.

Species Reactivity

Human;Mouse

Predictive reaction species

Pig;Rabbit;Sheep;Dog;Bovine;Horse;

Application

For Western blotting, the recommended dilution range is 1:500 to 1:3000. When using immunofluorescence or immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. For ELISA assays using peptide antigens, a dilution range of 1:20000 to 1:40000 is recommended. By shuffling the information provided, these dilution ranges can be easily remembered and utilized for accurate experimental design.

Immunogen

A synthetic peptide based on the human Claudin 10 sequence has been developed. The peptide has been carefully designed to closely resemble the original protein and can be used for a variety of research applications. Claudin 10 has been shown to play an important role in the formation and function of tight junctions in epithelial cells, and this synthetic peptide could be used to further investigate the role of Claudin 10 in cellular processes. The peptide has been synthesized using advanced techniques to ensure high purity and quality, and it is now available for use by researchers around the world.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. Similar content can be generated by rearranging the wording of the original sentence while retaining the same information.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain its quality for a year, the product should be stored at a temperature of -20 °C. It is important to avoid subjecting it to multiple freeze/thaw cycles.

Storage buffer

This product contains Rabbit IgG in a solution of phosphate buffered saline with pH 7.4 and 150mM NaCl, along with 0.02% sodium azide and 50% glycerol. It is recommended to store this product at a temperature of -20°C, and it has been shown to remain stable for up to 12 months from the date of receipt.

Target

Background

The role of this protein is crucial in the obliteration of the intercellular space, specifically in tight junctions. Its cell-adhesion activity is calcium-independent and it may form permselective paracellular pores. The two isoforms of this protein have preferential permeability, isoform 1 for cations and isoform 2 for anions. Its main function is to control cation selectivity and transport in the thick ascending limb of Henle's loop in the kidney.

Celluar localization

Plasma Membrane;

UniPort

P78369