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Rabbit Anti-CCR1 Polyclonal Antibody#abs133089

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Description

Catalog-specification	Delivery time	USD price
abs133089-100ug	1-2 Weeks	301.0
abs133089-50ug	1-2 Weeks	201.0

Overview
catalog	abs133089
Description	CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex, is responsible for regulating various cellular processes. It plays a crucial role in activating cyclin-associated kinases like CDK1, CDK2, CDK4, and CDK6 through threonine phosphorylation. Additionally, CAK forms a complex with the core-TFIIH basal transcription factor to activate RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A). This phosphorylation event allows RNA polymerase II to escape the promoter and initiate elongation of the transcripts. CDK7's activity and expression remain constant throughout the cell cycle. It is pivotal for both cell cycle control and RNA transcription by RNA polymerase II.
Other names	CCR1, also known as C-C chemokine receptor type 1 or CC CKR-1, is a protein encoded by the gene CD191. It is a receptor for chemokines in the C-C motif. Other names for this protein include CD191 antigen, CMKBR1, LD78 receptor, and RANTES receptor. CCR1 plays a crucial role in the immune system by mediating the recruitment of leukocytes to sites of inflammation. It specifically binds to chemokines such as MIP-1α, RANTES, and LD78. Activation of CCR1 leads to the initiation of various cellular responses, including cell migration and inflammatory signaling. The importance of CCR1 in immune response and inflammation has made it a potential therapeutic target for diseases such as rheumatoid arthritis, asthma, and multiple sclerosis. Research on CCR1 aims to understand its role in these diseases and develop interventions to modulate its activity. In summary, CCR1 is a chemokine receptor that plays a vital role in immune response and inflammation. Its interaction with specific chemokines regulates leukocyte recruitment and inflammatory signaling. Further investigation into CCR1 may contribute to the development of novel treatments for inflammatory disorders.
Source	Rabbit
Specificity	The antibody CCR1 recognizes and specifically binds to the naturally occurring levels of CCR1 protein in a sample. It allows for the detection of total CCR1 expression in cells or tissues without any manipulation or modification. This antibody provides valuable insights into the abundance and distribution of CCR1 in its native form.
Species Reactivity	Human
Antigen	CCR1
Application	The recommended dilutions for WB are between 1:500 and 1:2000, while for IHC, the optimal range is between 1:50 and 1:200. For optimal ELISA results with peptide substrates, the recommended dilution is between 1:20000 and 1:40000. These dilutions should be considered as starting points for further optimization based on the specific experimental conditions. It is also important to ensure that appropriate positive and negative controls are included in the assay to help verify the specificity and accuracy of the results. Overall, careful optimization of the experimental conditions is essential for achieving the most reliable and reproducible results.
Immunogen	A synthesized peptide.
MW	37.6 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Tissue specificity	Widely expressed in different hematopoietic cells.
Celluar localization	Plasma Membrane;
UniPort	P32246