Rabbit Anti-CD147 Polyclonal Antibody #abs120129

abs120129-50ul

In Stock

201

abs120129-100ul

In Stock

301

Other names

Basigin, also known as CD147 or TCSF, is a protein that plays a role in various physiological and pathological processes. It is expressed in a variety of tissues and cell types, including blood cells, endothelial cells, and neurons.
One of the functions of Basigin is its involvement in the formation of the blood-brain barrier, which is a highly specialized structure that separates the central nervous system from the rest of the body. Basigin is also involved in the regulation of matrix metalloproteinases, enzymes that break down the extracellular matrix in normal physiological processes such as tissue remodeling and pathological processes such as cancer invasion and metastasis.
Basigin has also been identified as a receptor for numerous pathogens, including the malaria parasite, the SARS-CoV virus, and the hepatitis C virus.
Studies have shown that Basigin may be a potential target for the diagnosis and treatment of various diseases, including cancer, Alzheimer's disease, and viral infections. It is therefore an important area of research in the fields of medicine and biotechnology.

Source

Rabbit

Specificity

CD147

Species Reactivity

;;;;;;;;;。，。

Application

ELISA is performed using a dilution ratio of 1:500-1000, while IHC-P and IHC-F require a dilution ratio of 1:400-800. Flow cytometry involves using 1μg of the sample per test, while IF is performed using a dilution ratio of 1:100-500. It is important to note that antigen retrieval is necessary for paraffin sections in IF.

Immunogen

A synthetic peptide derived from human TCSF:301-385/38 has been conjugated with KLH. To produce similar content, it can be rearranged as KLH has been attached to a synthetic peptide that is derived from the human TCSF at the 301-385/38 position.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To ensure optimal storage of the product, it is recommended to keep it at a temperature of -20 °C for up to one year. To maintain the quality of the product, it is important to avoid any repeated freeze/thaw cycles. Please make sure to follow these storage recommendations to ensure the longevity and effectiveness of the product.

Storage buffer

0.01M TBS (pH7.4)、1% BSA、0.03% Proclin30050% Glycerol。。。

Research area

Tumor immunology focuses on understanding the interaction between tumors and the immune system. One aspect of this field involves studying the synthesis and degradation of cell surface molecules related to tumor immunity.
Researchers in tumor immunology investigate how tumor cells synthesize specific molecules on their cell surface that allow them to interact with the immune system. These molecules, such as immune checkpoints, can either inhibit or enhance immune responses against tumors. Their synthesis is influenced by various factors, including the genetic makeup of the tumor cells and the signaling pathways that regulate their expression.
Additionally, tumor immunologists study the degradation of cell surface molecules involved in tumor immunity. Some tumors evade immune recognition by downregulating or shedding molecules that are crucial for immune recognition and response. This process helps tumors evade the immune system's surveillance and enables their growth and metastasis.
Understanding the synthesis and degradation of cell surface molecules in tumor immunology is crucial for developing new strategies to enhance anti-tumor immune responses. Researchers aim to identify therapeutic targets that can modulate the synthesis and degradation of these molecules, either by blocking inhibitory checkpoints or enhancing immune-stimulatory molecules.
Overall, tumor immunology investigates how tumors manipulate their cell surface molecules to evade immune responses. By studying the synthesis and degradation of these molecules, researchers seek to develop innovative approaches to improve the effectiveness of cancer immunotherapy and ultimately find a cure for cancer.

Target

Background

Spermatogenesis, embryo implantation, neural network formation, and tumor progression are all critical processes in which the plasma membrane protein encoded by this gene plays a vital role. Additionally, this protein belongs to the immunoglobulin superfamily, highlighting its significance in immune response. Numerous transcript variants have been discovered for this gene, resulting in the production of different isoforms. The importance of this gene and its protein in various biological events underscores its multifaceted nature and potential implications in diverse physiological and pathological contexts.

Celluar localization

Cell membrane

UniPort

P35613