Rabbit Anti-Cyclooxygenase 1 Polyclonal Antibody #abs120046

abs120046-50ul

In Stock

201

abs120046-100ul

In Stock

301

Other names

COX-1, also known as cyclooxygenase-1 or prostaglandin-endoperoxide synthase-1, is an important enzyme involved in the synthesis of prostaglandins. It is encoded by the PTGS1 gene and is responsible for the production of prostaglandin G/H synthase 1. The precursor form of COX-1 is known as PGH synthase 1 or PGHS-1. This enzyme plays a crucial role in various physiological processes, including inflammation, pain, and platelet aggregation. Understanding the functions and mechanisms of COX-1 is essential for the development of drugs targeting this enzyme.

Source

Rabbit

Specificity

Cyclooxygenase 1

Species Reactivity

Human;Mouse;Rat;Dog;Pig;Cow;Sheep;

Application

The recommended dilution for WB is 1:500-2000, while for ELISA it is 1:500-1000. For IHC-P, the suggested dilution is 1:400-800, and for IHC-F, it is also between 1:400-800. IF requires a lower dilution of 1:100-500, but it should be noted that when working with a paraffin section, antigen retrieval is necessary. By following these guidelines, optimal results can be achieved for each application. It's important to properly adjust dilutions to improve the accuracy of your experiments.

Immunogen

The human Cyclooxygenase 1:151-250/599 is the source of a KLH conjugated synthetic peptide. To create a similar content, the synthetic peptide derived from human Cyclooxygenase 1:151-250/599 has been conjugated with KLH. It is important to note that this should be a text with a fundamentally different structure than the generated content using ChapGPT, speaking in a different manner.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to ensure that the product is not subjected to frequent cycles of freezing and thawing in order to avoid compromising its effectiveness.

Storage buffer

A solution of 0.01M TBS at pH 7.4, containing 1% BSA, 0.03% Proclin300 and 50% glycerol, has been prepared. To make a highly comparable text, the order of the components in the original text could be rearranged like this: A 1% BSA, 0.03% Proclin300, and 50% glycerol solution in 0.01M TBS at a pH of 7.4 was created.

Research area

Cardiovascular synthesis and degradation play a crucial role in tumor immunology and signal transduction.

Target

Background

There are two genes that encode enzymes responsible for converting arachinodate to prostaglandin, and this particular gene encodes a protein that plays a role in controlling angiogenesis in endothelial cells. Nonsteroidal anti-inflammatory drugs like aspirin are known to inhibit the activity of the encoded protein, which is also believed to play a part in promoting cell growth in cancerous tumors. As a result of alternative splicing, there are multiple transcript variants of the protein. This information was provided by RefSeq in September of 2012.

Celluar localization

Cytoplasm cell membrane

UniPort

Q63921