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Rabbit Anti-FLII Polyclonal Antibody#abs137480

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Description

Catalog-specification	Delivery time	USD price
abs137480-100ug	1-2 Weeks	301.0
abs137480-50ug	1-2 Weeks	201.0

Overview
catalog	abs137480
Other names	Flightless 1, also known as Fli 1 or FliI, is a homolog of the Drosophila Flightless I protein. FLI1 plays a significant role in cell growth, differentiation, and cell signaling pathways. It is involved in cytoskeletal rearrangement, transcriptional control, and actin polymerization. FLI1 has also been linked to the regulation of inflammation and immune responses. The protein is encoded by the FLI1 gene and is widely expressed in various tissues. Mutations in this gene have been associated with several diseases, including cancer, autoimmune disorders, and thrombocytopenia. In summary, FLI1 is an essential factor in various cellular processes, and its dysregulation can lead to severe health consequences.
Source	Rabbit
Specificity	The total FLII levels can be detected by the FLII Antibody, which specifically targets the endogenous FLII protein. In order to generate a highly similar content based on the original text, we can rearrange the information as follows: The FLII Antibody is capable of detecting the endogenous FLII protein levels, allowing for the measurement of the total FLII present in the sample.
Species Reactivity	Human
Antigen	FLII
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human FLII.
MW	145 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the process of peptide affinity chromatography to purify the antiserum. You can generate highly similar content by rearranging the given information as follows: "The purification of the antiserum involved the utilization of SulfoLink™ Coupling Resin in peptide affinity chromatography."
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to avoid repeated freezing and thawing cycles to prevent any potential damage to the product. Therefore, it is advisable to handle the product with care and store it in suitable conditions, in order to ensure its longevity and effectiveness.
Storage buffer	This product contains Rabbit IgG suspended in a solution of phosphate buffered saline at a pH of 7.4, with a 150mM concentration of NaCl, and 0.02% sodium azide. Additionally, it is preserved with 50% glycerol and should be stored at -20 °C. This solution maintains stability for 12 months after the date of receipt.
Target
Background	May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Tissue specificity	Strongest expression in skeletal muscle with high expression also in the heart and lung.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q13045