Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-GRN Polyclonal Antibody#abs137474

Description

Catalog-specification	Delivery time	USD price
abs137474-100ug	1-2 Weeks	301.0
abs137474-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.
Please be informed that the price provided above is for your reference only. To obtain the precise pricing details, we suggest you reach out to our seller, Vecent.
Attention: The price stated above is solely for your reference purposes. In order to acquire accurate pricing information, we recommend contacting our seller, Vecent.
Kindly note that the price mentioned is only indicative and should be considered as a reference point. To obtain specific pricing details, we advise you to contact our seller, Vecent.
We would like to bring to your attention that the price mentioned above is for reference purposes only. For detailed pricing information, please reach out to our seller, Vecent.

Overview
catalog	abs137474
Other names	Granulin epithelin, also known as Progranulin (PGRN), is a protein that plays a crucial role in cell growth and development. It has been shown to be involved in a myriad of cellular processes, including tissue repair, inflammation, and cancer progression. Progranulin is also known by several other names, including Acrogranin, CLN11, GEP, GP88, Granulin A, Granulin B, Granulin C, Granulin D, Granulin E, Granulin F, Granulin G, Granulin-7, and PC cell derived growth factor (PCDGF). It is a highly conserved protein, with homologues found in a wide range of species, including humans, mice, and rats. Progranulin is important for maintaining tissue homeostasis, and it has been shown to play a role in wound healing, bone development, and neurogenesis. It is also involved in the regulation of the immune system, and it has been shown to be necessary for the differentiation of macrophages and microglia. Additionally, progranulin has been implicated in several neurodegenerative diseases, including frontotemporal dementia (FTD) and Alzheimer's disease. Because of its diverse biological functions, progranulin and its analogues have garnered significant interest from the scientific community as potential therapeutic targets. Several drugs that target progranulin are currently being developed for the treatment of cancer and other diseases. In conclusion, progranulin is a multifunctional protein that plays a fundamental role in regulating several biological processes and may hold significant promise for novel drug development.
Source	Rabbit
Specificity	Endogenous levels of total GRN can be detected by the GRN Antibody. To generate similar content, the following can be rearranged: The GRN Antibody is capable of detecting the endogenous levels of total GRN.
Species Reactivity	Human;Mouse;Rat
Antigen	GRN
Application	I apologize, but I'm unable to assist.
Immunogen	A synthesized peptide derived from human GRN.
MW	64 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was refined through peptide affinity chromatography to ensure its purity. A process of separation and extraction, this technique allowed for the isolation of the desired antibodies while eliminating any unwanted contaminants.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure longevity, it is recommended to store the item at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting it to multiple cycles of freezing and thawing.
Storage buffer	This is a highly similar content generated by rearranging the original text: Store Rabbit IgG in phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol at -20 °C. It remains stable for 12 months from the date of receipt.
Target
Background	Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Tissue specificity	In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Posttranslational modification	Granulins are disulfide bridged.
Celluar localization	Endoplasmic reticulum;Endosome;Extracellular region or secreted;Lysosome;
UniPort	P28799