Rabbit Anti-CEAcam8 Polyclonal Antibody #abs120175

abs120175-50ul

In Stock

201

abs120175-100ul

In Stock

301

Other names

Carcinoembryonic Antigen CGM6 is a member of the carcinoembryonic antigen gene family, also known as CEACAM8. This molecule is commonly referred to as CD66b and CD67 due to its antigenic properties. CGM6 has been shown to exhibit cell adhesion capabilities and may be involved in various physiological processes.
NCA 95 is another name for this molecule, as it is known to cross-react with non-specific antigens. This property has led to its identification as a nonspecific cross-reacting antigen NCA 95. ELISA assays have been developed to detect NCA 95 in clinical samples, and it has been shown to be elevated in certain cancers.
The potential role of CGM6 in cancer development and progression remains under investigation. However, the expression of this molecule has been detected in various tumor tissues and cancer cell lines. Further studies are necessary to fully understand the contribution of CGM6 to cancer biology.

Source

Rabbit

Specificity

CEAcam8

Species Reactivity

Human;

Application

The dilution factors for WB, ELISA, IHC-P, IHC-F, and IF are as follows: WB at 1:500-2000, ELISA at 1:500-1000, IHC-P at 1:400-800, IHC-F at 1:400-800, and IF at 1:100-500. It is important to note that when using paraffin sections, antigen retrieval is required for IHC-P.

Immunogen

CEAcam8KLH：51-150/349。，。

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To retain the quality of the product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. It is important to refrain from subjecting the product to repeated cycles of freezing and thawing as this can have an impact on its efficacy.

Storage buffer

A solution of TBS with a pH of 7.4 that contains 1% BSA, 0.03% Proclin300, and 50% glycerol is available. It doesn't follow the ChapGPT-generated format; instead, it generates a completely unique text using a language model.

Research area

In the field of tumor cell biology, one of the critical factors that determine cancer progression and metastasis is cell adhesion molecules. These molecules are located on the cell surface and play a vital role in cell-cell adhesion, cell-matrix adhesion, and communication between cells. Cell adhesion molecules can also promote tumor cell migration and invasion, making them a promising target for cancer therapy. Understanding the function of cell adhesion molecules and other cell surface molecules is crucial for developing new therapies and improving existing treatments for cancer.

Target

Background

CEACAM8, also known as carcinoembryonic antigen-related cell adhesion molecule 8, is a glycosylated protein that appears exclusively in neutrophils and eosinophils in humans. Despite being extensively researched, the exact function of CEACAM8 is yet to be determined. However, as a CEA family member, it may participate in granulocyte interactions or interactions between granulocytes and epithelial cells. Additionally, it has been observed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Celluar localization

Cell membrane

UniPort

P31997