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Rabbit Anti-ENaC Gamma Polyclonal Antibody#abs138060

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Description

Catalog-specification	Delivery time	USD price
abs138060-100ug	1-2 Weeks	301.0
abs138060-50ug	1-2 Weeks	201.0

Overview
catalog	abs138060
Other names	The Amiloride-sensitive sodium channel subunit gamma, also known as ENaC gamma subunit or Gamma-ENaC, is a crucial component of the epithelial sodium channel. It is expressed in various tissues, including the lungs, kidneys, and colon, and plays a vital role in salt and water homeostasis. The channel is activated by hormones such as aldosterone and controls sodium reabsorption in the distal nephron of the kidney. It is also involved in the regulation of electrolyte balance and blood pressure. Mutations in the ENaC gamma subunit have been associated with a rare genetic disorder known as pseudohypoaldosteronism type 1 (PHA1), which results in salt-wasting and dehydration. Consequently, understanding the function of this subunit is essential for developing therapies for PHA1 and related disorders.
Source	Rabbit
Specificity	The endogenous levels of total ENaC γ can be detected using the ENaC γ Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	ENaC gamma
Application	(WB)1:10001:3000，(IF)(ICC)1:1001:500。(ELISA)，1:200001:40000。。
Immunogen	A synthesized peptide derived from human ENaC γ.
MW	74 kDa
Properties
Concentration	1mg/ml
purification	We used SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. Let me generate a highly similar content for you based on the original text information. The purification of the antiserum involved the use of SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the product stored at a temperature of -20 °C for up to a year. It's important to avoid exposing it to repeated freeze and thaw cycles to ensure its stability.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Tissue specificity	Expressed in kidney (at protein level).
Posttranslational modification	Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	P51170