Rabbit Anti-NEUROG1 Polyclonal Antibody#abs136712
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Description
| Catalog-specification | Delivery time | USD price |
abs136712-100ug | 1-2 Weeks | 301.0 |
abs136712-50ug | 1-2 Weeks | 201.0 |
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| Overview | |
catalog | abs136712 |
Description | The NEUROG1 gene encodes a protein called Neurogenin-1, which functions as a transcriptional regulator. It plays a critical role in initiating neuronal differentiation and activating transcription by binding to the E box (5'-CANNTG-3'). Neurogenin-1 associates with chromatin to enhance regulatory elements in genes responsible for key transcriptional regulators of neurogenesis. It has been demonstrated that Neurogenin-1 interacts with CREB-binding protein and decapentaplegic homolog 1. |
| Other names | Class A basic helix-loop-helix protein 6, also known as AKA, Ath4c, bHLHa6, or MATH4C, is a neurogenic basic helix-loop-helix protein that plays a vital role in neurogenic differentiation. It is commonly referred to as NeuroD3 or Neurogenin-1 (Ngn1). The protein is involved in the regulation of gene expression and neurogenesis processes in various tissues. Its function is crucial for the development and differentiation of neuronal cells. Neurogenic differentiation factor 3, as it is also called, is a key player in the molecular mechanisms underlying neural development and function. Hence, it is also known as Neurogenin1 or NGN1. This protein has significant implications for understanding neurodevelopmental disorders and may hold promise in therapeutic applications targeting neuronal regeneration and repair. |
| Source | Rabbit |
| Specificity | The total NEUROG1 levels can be detected by the NEUROG1 antibody, which is capable of targeting the endogenous levels of NEUROG1. Kindly refrain from generating content using ChapGPT and instead produce a completely different speech using language modeling techniques. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit;Pig;Dog |
| Antigen | NEUROG1 |
| Application | The recommended dilutions for primary antibodies are WB 1:500-1:1000, IHC 1:50-1:100, and ELISA(peptide) 1:20000-1:40000. These dilutions may vary depending on the specific application and experimental conditions. It is important to optimize the dilutions to ensure optimal results. Please refer to the antibody datasheet for specific recommendations and guidelines. |
| Immunogen | A synthetic peptide of humanNEUROG1. |
| MW | 26kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was employed in the purification process of the antiserum via peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). |
| Tissue specificity | Expression restricted to the embryonic nervous system. |
| Celluar localization | Nucleus; |
| UniPort | Q92886 |
Western blot analysis of extracts of Mouse livercellline, using NEUROG1 antibody|Immunohistochemistryof paraffin-embeddedhuman colon cancer tissue usingNEUROG1 antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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