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Rabbit Anti-Endo G Polyclonal Antibody#abs138061

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Description

Catalog-specification	Delivery time	USD price
abs138061-100ug	1-2 Weeks	301.0
abs138061-50ug	1-2 Weeks	201.0

Overview
catalog	abs138061
Other names	EndoG, also called Endonuclease G or Mitochondrial Endonuclease G, is a human enzyme that plays a critical role in DNA fragmentation during apoptosis. It is encoded by the FLJ27463 gene and mainly localized in the mitochondria. EndoG is a conserved protein with homologs in many eukaryotic organisms. Its primary function is to cleave double-stranded DNA into small fragments in a Ca(2+)-dependent manner. This process is essential for dismantling the chromatin structure and ultimately leads to cell death. EndoG is a promising therapeutic target for cancer and neurodegenerative diseases, as well as a potential biomarker for cell death.
Source	Rabbit
Specificity	The Endo G Antibody is capable of detecting the total amount of endogenous Endo G present in a sample. This means that it can accurately determine the levels of this protein in cells or tissues without the need for external factors. With this antibody, researchers can gain a better understanding of the role that Endo G plays in biological processes and potentially develop treatments for related conditions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine;Pig;Sheep
Antigen	Endo G
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Endo G.
MW	32 kDa
Properties
Concentration	1mg/ml
purification	The process of purifying the antiserum involved utilizing SulfoLink™ Coupling Resin in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the material, keep it in a freezer at a temperature of -20 °C for a duration of one year. Be sure to prevent any instances where the material freezes and thaws repeatedly.
Storage buffer	Phosphate buffered saline containing Rabbit IgG is a stable solution with a pH of 7.4. It also consists of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation is recommended to be stored at a temperature of -20 °C. It is important to note that this product remains stable for a period of 12 months from the date of receipt.
Target
Background	Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).
Celluar localization	Cytosol;Mitochondrion;Nucleus;
UniPort	Q14249