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Rabbit Anti-FES Polyclonal Antibody#abs136551

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Description

Catalog-specification	Delivery time	USD price
abs136551-50ug	1-2 Weeks	201.0
abs136551-100ug	1-2 Weeks	301.0

Overview
catalog	abs136551
Other names	FES is a proto-oncogene tyrosine protein kinase that is also known as FPS or cFES. It is a homolog of the feline sarcoma (Snyder-Theilen) viral (v-fes) and Fujinami avian sarcoma (PRCII) viral (v fps) oncogenes. The feline sarcoma oncogene is involved in the development of many cancers, including sarcomas and leukemias. The FES gene is localized to the q region of chromosome 15 and produces a protein that plays a major role in the regulation of cell growth and differentiation. The protein is often expressed in a variety of tissues, including the brain, hematopoietic cells, and smooth muscle cells. The FES protein has been found to play a crucial role in a wide range of physiological processes, including immune system responses, cell signaling, and tissue repair. As such, it is an important target for future research into cancer therapies and treatments.
Source	Rabbit
Specificity	The FES Antibody is capable of detecting total FES protein at endogenous levels. The antibody is designed to specifically bind to FES and thereby facilitates the detection of total FES levels in the sample. It is essential in the study of FES protein dynamics and signaling pathways as it enables the identification and quantification of the protein in various biological samples. The use of the FES Antibody in research has therefore significantly contributed to the advancement of knowledge on the function and regulation of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	FES
Application	To conduct effective protein analysis, it is recommended to use a specific dilution ratio for various techniques such as western blotting and immunohistochemistry. For Western blotting, a dilution ratio of 1:500-1:2000 is suggested. Similarly, for immunohistochemistry, a dilution ratio of 1:50-1:200 is considered optimal. For ELISA using peptide, a dilution ratio of 1:20000-1:40000 is recommended. Following these recommended dilution ratios can greatly improve the accuracy and sensitivity of protein analysis.
Immunogen	A synthesized peptide derived from human FES.
MW	93kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the antiserum was purified via peptide affinity chromatography. This process ensured optimal purity levels were achieved, producing a high-quality end result.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. To prevent any damage, it is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Tissue specificity	Widely expressed. Detected in adult colon epithelium.
Posttranslational modification	Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
Celluar localization	Cytoskeleton;Cytosol;Golgi apparatus;Plasma Membrane;
UniPort	P07332