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Rabbit Anti-CYP19A1 Polyclonal Antibody#abs136404

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Description

Catalog-specification	Delivery time	USD price
abs136404-100ug	1-2 Weeks	301.0
abs136404-50ug	1-2 Weeks	201.0

Overview
catalog	abs136404
Description	CYP19A1, also known as ARO1 or aromatase, is a member of the cytochrome P450 family. It functions as a terminal enzyme located in the endoplasmic reticulum of various tissues, converting androgens to estrogens irreversibly. Additionally, it is referred to as CYAR, CYP19, and estrogen synthase. The protein encoded by the CYP19A1 gene has a molecular weight ranging from 46 kDa to 69 kDa. Although the protein can undergo glycosylation, the extent of glycosylation does not appear to be crucial for its activity. Notably, in the brain, aromatase synthesized by CYP19A1 may play a neuroprotective role by increasing estrogen levels in damaged neurons. Consequently, genetic variations in the brain aromatase gene could potentially influence the risk of developing Alzheimer's disease. To sum up, this specific antibody is specifically designed to target CYP19A1.
Other names	The gene ARO, also known as ARO1, encodes for the enzyme aromatase, which is responsible for the conversion of androgens to estrogens. It is also known by various other names such as CP19A_HUMAN, CPV1, CYAR, CYP19, Cyp19a1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), Estrogen synthase, Estrogen synthetase, Flavoprotein linked monooxygenase, MGC104309, Microsomal monooxygenase, OTTHUMP00000162543, OTTHUMP00000198350, and P 450AROM. Please generate a highly similar content by rearranging the above content, ensuring that the generated content is based on the original text information.
Source	Rabbit
Specificity	The levels of total CYP19A1 can be detected by using the CYP19A1 antibody. This antibody is specifically designed to recognize and bind to the endogenous form of CYP19A1.
Species Reactivity	Human;Mouse;Rat
Antigen	CYP19A1
Application	The recommended dilutions for various applications are as follows: for Western blotting, use a dilution range of 1:500 to 1:2000; for immunohistochemistry, use a dilution range of 1:50 to 1:200; for immunofluorescence or immunocytochemistry, use a dilution range of 1:100 to 1:500; and for ELISA with peptide, use a dilution range of 1:20000 to 1:40000. These dilution ranges have been optimized for optimal results in each application and should be followed closely for reliable and reproducible results.
Immunogen	A synthesized peptide derived from human CYP19A1.
MW	58kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Tissue specificity	Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Posttranslational modification	Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).
Celluar localization	Endoplasmic reticulum;
UniPort	P11511