Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-POT1 Polyclonal Antibody#abs137900

Please note that the price mentioned above is for your reference only. For the exact price, kindly get in touch with our seller Vecent. It is important to emphasize that the information provided in this message is subject to variation and needs to be confirmed through direct communication with...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs137900-100ug	1-2 Weeks	301.0
abs137900-50ug	1-2 Weeks	201.0

Overview
catalog	abs137900
Other names	POT1 (protection of telomeres 1) is a protein known as POT1-like telomere end-binding protein. It is also referred to as POT1 protection of telomeres 1 homolog or Protection of telomeres 1 homolog (S. pombe). POT1 plays a crucial role in maintaining the integrity and stability of telomeres. Telomeres are the protective caps located at the ends of chromosomes, and POT1 is responsible for safeguarding these telomeres. The protein POT1 plays a crucial role in preventing the deterioration and shortening of telomeres, which is associated with aging and various diseases. Thus, POT1 is an important player in maintaining the genomic stability and preserving the functionality of cells.
Source	Rabbit
Specificity	The total POT1 is detected by the POT1 Antibody, which can accurately measure the endogenous levels of POT1.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	POT1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human POT1.
MW	71 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out via peptide affinity chromatography. A highly similar content can be created by rearranging the phrasing of the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal preservation, it is recommended to store the product at a temperature of -20°C for a duration of one year. It is important to note that repeated freeze/thaw cycles should be avoided to maintain the quality of the product.
Storage buffer	The Rabbit IgG in phosphate buffered saline is a reliable product that has a long shelf life. It is stored in a solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, and must be kept at a temperature of -20 °C. This ensures that its properties are fully preserved and it remains stable for up to 12 months from the date of receipt. Our Rabbit IgG is a valuable asset for researchers and individuals alike, offering high quality and consistent results for a wide range of applications.
Target
Background	Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
Tissue specificity	Ubiquitous.
Celluar localization	Nucleus;
UniPort	Q9NUX5