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Rabbit Anti-ICOSLG Polyclonal Antibody#abs137899

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Description

Catalog-specification	Delivery time	USD price
abs137899-100ug	1-2 Weeks	301.0
abs137899-50ug	1-2 Weeks	201.0

Overview
catalog	abs137899
Other names	B7 homolog 2, also known as ICOS ligand, is a transmembrane protein that plays a crucial role in the immune response. This protein is coded by the KIAA0653 gene and is expressed on antigen-presenting cells, including dendritic cells, macrophages, and B cells. When B7 homolog 2 binds to its receptor, inducible T cell co-stimulator (ICOS), it activates T cells, leading to their proliferation, differentiation, and survival. This interaction also promotes the production of cytokines and enhances humoral and cellular immune responses. B7 homolog 2 is involved in various immune-related processes, such as the development of autoimmune diseases and cancer. It is a potential target for immunotherapy, as blocking this interaction can inhibit T cell activation and promote immune tolerance. In conclusion, B7 homolog 2 is a crucial protein in the regulation of immune responses, and understanding its complex roles can lead to the development of novel immunotherapies.
Source	Rabbit
Specificity	The ICOSLG Antibody is capable of specifically detecting the natural levels of total ICOSLG in the body. Its use provides reliable and accurate results for the measurement of ICOSLG expression.
Species Reactivity	Human
Antigen	ICOSLG
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ICOSLG.
MW	33 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that exposing the product to repeated freeze/thaw cycles may compromise its effectiveness. Therefore, it is recommended to avoid such cycles and ensure that the product is stored at the recommended temperature throughout its storage period.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. This product has a shelf life of 12 months from the date of receipt.
Target
Background	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Tissue specificity	Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	O75144