Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ME1 Polyclonal Antibody#abs134519

Please note that the price provided is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Kindly refrain from using ChapGPT to generate conversation in a similar manner as the original text. Instead, let's focus on generating speech using a...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs134519-100ug	1-2 Weeks	301.0
abs134519-50ug	1-2 Weeks	201.0

Overview
catalog	abs134519
Other names	Malic enzyme 1, also known as cytosolic malic enzyme 1 or NADP-dependent malic enzyme, plays a crucial role in cellular metabolism. This enzyme, encoded by the HUMNDME gene, is responsible for the conversion of malate to pyruvate and produces NADPH in the process. It is primarily found in the cytosol, where it facilitates various metabolic pathways. Malic enzyme 1 is essential for the metabolism of carbohydrates and lipids. It participates in the citric acid cycle by catalyzing the oxidative decarboxylation of malate, leading to the production of pyruvate and NADPH. Pyruvate can then be further utilized in energy production or other metabolic processes. NADPH, on the other hand, serves as a cofactor in various biosynthetic reactions, including fatty acid and cholesterol synthesis. The importance of malic enzyme 1 extends beyond its role in energy production and biosynthesis. Studies have demonstrated its involvement in cancer metabolism and oxidative stress response. Malic enzyme 1 has been found to be upregulated in certain cancers, promoting tumor growth and survival. Additionally, it plays a crucial role in maintaining the redox balance within cells by generating NADPH, which acts as a vital antioxidant. In summary, malic enzyme 1 is a key enzyme in cellular metabolism. Its cytosolic localization and NADP-dependent activity make it vital for various metabolic processes, including energy production, biosynthesis, and antioxidant defense. Understanding the functions and regulation of malic enzyme 1 could contribute to the development of therapeutic strategies targeting metabolic disorders and cancer.
Source	Rabbit
Specificity	The detection of endogenous levels of total ME1 is enabled by the ME1 Antibody. To emphasize, the generated content should be based on the given information while being presented in a significantly different manner.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Bovine;Horse;Pig;
Antigen	ME1
Application	1:500~1:1000。（IF）/（ICC）1:100-1:500。，（ELISA），1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	64 KD
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, we employed peptide affinity chromatography to refine the antiserum and create a pure end product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of minus 20 degrees Celsius for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this could negatively affect its properties. It is best to follow these storage guidelines to ensure the product remains effective and safe to use.
Storage buffer	Phosphate buffered saline containing rabbit IgG is available with a formulation of pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Proper storage of this product is at -20 °C, and it maintains stability for a period of 12 months from the date of receipt.
Target
Background	(S)-malate + NADP+ = pyruvate + CO2 + NADPH.
Tissue specificity	Expressed in all tissues tested including liver, placenta and white adipose tissue.
Celluar localization	Cytosol;Mitochondrion;
UniPort	P48163